Huang H, Shen H, Qin Z, Jiang D D, Han J L, Wang L, Wang W
Institute of Respiratory Diseases, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2016 Sep;39(9):709-13. doi: 10.3760/cma.j.issn.1001-0939.2016.09.010.
To objectively evaluate visual function by pattern visual evoked potential (PVEP) and its related factors in patients with obstructive sleep apnea syndrome (OSAS)without any ocular symptoms.
Eighty-three newly diagnosed OSAS and 18 normal subjects were enrolled in the study. The OSAS patients were divided into mild (n=11), moderate(n=17) and severe (n=55) groups based on the apnea-hypopnea index(AHI). Before the polysomnography(PSG) test, all participants underwent a PVEP examination measuring the latency and amplitude of P100.
Compared to healthy controls, the latency of P100 was significantly increased in OSAS patients [controls group: 97(95-100) ms, mild OSAS group: 101(98-103) ms, moderate OSAS group: 101(98-105) ms, severe OSAS group: 105(101-108) ms, all P<0.05], and the amplitude of P100 was significantly reduced [controls group: 9(8-10) μV, mild OSAS group: 7(5-8) μV, moderate OSAS group: 6(5-7) μV, severe OSAS group: 6(4-7) μV, all P<0.05]. The severe group showed significantly longer latency of P100 when compared with mild and moderate groups(P<0.05). In the OSAS patients, univariate analysis showed that, the latency of P100 was correlated with ODI, T90, AHI, sleep efficiency, minimum SaO2, and mean SaO2, and the amplitude of P100 was statistically associated with sleep efficiency .But the stepwise multiple linear regression analysis revealed that only AHI was significantly correlated with the latency of P100 (r=0.275, P<0.01).
Abnormal PVEP was found in patients with OSAS without any clinical manifestations of the optic neuropathy. The dysfunction of optic nerve was significantly associated with AHI and sleep efficiency.
通过图形视觉诱发电位（PVEP）及其相关因素客观评估无任何眼部症状的阻塞性睡眠呼吸暂停综合征（OSAS）患者的视功能。
本研究纳入83例新诊断的OSAS患者和18名正常受试者。根据呼吸暂停低通气指数（AHI）将OSAS患者分为轻度（n = 11）、中度（n = 17）和重度（n = 55）组。在多导睡眠图（PSG）检查前，所有参与者均接受PVEP检查，测量P100的潜伏期和波幅。
与健康对照组相比，OSAS患者P100的潜伏期显著延长[对照组：97（95 - 100）ms，轻度OSAS组：101（98 - 103）ms，中度OSAS组：101（98 - 105）ms，重度OSAS组：105（101 - 108）ms，所有P < 0.05]，且P100的波幅显著降低[对照组：9（8 - 10）μV，轻度OSAS组：7（5 - 8）μV，中度OSAS组：6（5 - 7）μV，重度OSAS组：6（4 - 7）μV，所有P < 0.05]。重度组与轻度和中度组相比，P100的潜伏期显著更长（P < 0.05）。在OSAS患者中，单因素分析显示，P100的潜伏期与氧减指数（ODI）、T90、AHI、睡眠效率、最低血氧饱和度（SaO2）及平均SaO2相关，P100的波幅与睡眠效率有统计学关联。但逐步多元线性回归分析显示，仅AHI与P100的潜伏期显著相关（r = 0.275，P < 0.01）。
在无任何视神经病变临床表现的OSAS患者中发现PVEP异常。视神经功能障碍与AHI及睡眠效率显著相关。
