Centre International de recherche en Infectiologie, CIRI, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, Hospices Civils de Lyon, LYON, France.
Eur J Immunol. 2016 Sep;46(9):2095-8. doi: 10.1002/eji.201646584.
Recent studies of immune populations in nonlymphoid organs have highlighted the great diversity of the innate lymphoid system. It has also become apparent that mouse and human innate lymphoid cells (ILCs) have distinct phenotypes and properties. In this issue of the European Journal of Immunology, Harmon et al. [Eur. J. Immunol. 2016. 46: 2111-2120] characterized human hepatic NK-cell subsets. The authors report that hepatic CD56(bright) NK cells resemble mouse liver ILC1s in that they express CXCR6 and have an immature phenotype. However, unlike mouse ILC1s, they express high levels of Eomes and low levels of T-bet, and upon stimulation with tumor cells, secrete low amounts of cytokines. These unexpected findings further support the differences between human and mouse immune populations and prompt the study of the role of hepatic ILC subsets in immune responses.
最近对非淋巴器官免疫群体的研究强调了固有淋巴细胞系统的巨大多样性。显然，小鼠和人类固有淋巴细胞 (ILC) 具有不同的表型和特性。在本期的《欧洲免疫学杂志》上，Harmon 等人 [Eur. J. Immunol. 2016. 46: 2111-2120] 对人类肝脏 NK 细胞亚群进行了描述。作者报告说，肝脏 CD56(bright) NK 细胞类似于小鼠肝脏 ILC1，因为它们表达 CXCR6 并具有不成熟的表型。然而，与小鼠 ILC1 不同的是，它们表达高水平的 Eomes 和低水平的 T-bet，并且在受到肿瘤细胞刺激时，分泌少量细胞因子。这些出乎意料的发现进一步支持了人类和小鼠免疫群体之间的差异，并促使研究肝脏 ILC 亚群在免疫反应中的作用。
