Aw Yeang Han Xian, Piersma Sytse J, Lin Yiing, Yang Liping, Malkova Olga N, Miner Cathrine, Krupnick Alexander S, Chapman William C, Yokoyama Wayne M
Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Division of Transplant Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110.
J Immunol. 2017 Feb 15;198(4):1417-1422. doi: 10.4049/jimmunol.1601818. Epub 2017 Jan 16.
Most knowledge on NK cells is based on studies of what are now known as conventional NK cells in the mouse spleen or human peripheral blood. However, recent studies in mice indicate the presence of tissue-resident NK cells in certain organs, such as the liver, that display different markers and transcription factor dependencies as compared with conventional NK cells. In this study, we provide evidence from cytometry by time-of-flight analysis and humanized mice indicating that human CD49e NK cells are tissue resident in the liver. Thus, these studies indicate that tissue-resident NK cells are evolutionarily conserved in humans and mice, providing a foundation to explore their role in human disease.
关于自然杀伤（NK）细胞的大多数知识都基于对现在称为常规NK细胞的研究，这些研究对象是小鼠脾脏或人类外周血中的细胞。然而，最近对小鼠的研究表明，在某些器官（如肝脏）中存在组织驻留NK细胞，与常规NK细胞相比，它们表现出不同的标志物和转录因子依赖性。在本研究中，我们通过飞行时间分析流式细胞术和人源化小鼠提供了证据，表明人类CD49e NK细胞是肝脏中的组织驻留细胞。因此，这些研究表明，组织驻留NK细胞在人类和小鼠中具有进化保守性，为探索它们在人类疾病中的作用奠定了基础。
