Vasiliev N V
Tomsk Cancer Research Institute, Tomsk, Russia.
Arkh Patol. 2016 Jul-Aug;78(4):58-63. doi: 10.17116/patol201678458-62.
Lymph node metastasis of osteosarcomas is a rather rare phenomenon; according to different authors, the incidence of lymph node metastasis is 4 to 11%. The detection of lymph node metastases in osteosarcoma is associated with a significant reduction in the 5-year survival of patients and allows its classification as clinical stage IV tumor. The risk factors for lymph node metastases in patients with bone sarcomas are age (≥64 years), gender (female), nosological entity (undifferentiated pleomorphic sarcoma, osteosarcoma, chondrosarcoma), tumor depth (muscle, bone), and the size of primary tumor (>5 сm). The mechanism of lymph node metastasis of osteosarcomas seems to be related to mesenchymal-to-epithelial transition.
骨肉瘤的淋巴结转移是一种相当罕见的现象；根据不同作者的研究，淋巴结转移的发生率为4%至11%。骨肉瘤中淋巴结转移的检测与患者5年生存率的显著降低相关，并使其被归类为临床IV期肿瘤。骨肉瘤患者发生淋巴结转移的危险因素包括年龄（≥64岁）、性别（女性）、疾病实体（未分化多形性肉瘤、骨肉瘤、软骨肉瘤）、肿瘤深度（肌肉、骨骼）以及原发肿瘤大小（>5厘米）。骨肉瘤淋巴结转移的机制似乎与间充质向上皮转化有关。
