免疫组织化学与生化雌激素受体和孕激素受体分析：与组织学参数的相关性
Immunohistochemical versus biochemical estrogen-receptor and progesterone-receptor analysis: correlation with histological parameters.
作者信息
Helle M, Helin M, Isola J, Helin H
机构信息
Mikkeli Central Hospital, Finland.
出版信息
J Cancer Res Clin Oncol. 1989;115(4):361-5. doi: 10.1007/BF00400963.
Abstract
Human breast carcinomas were evaluated for estrogen and progesterone receptors by immunohistochemistry using monoclonal anti-receptor antibodies (n = 267) and by cytosol steroid-binding assays (n = 212). The estrogen and progesterone receptor contents of the tumors correlated with histological features of differentiation, such as histological and nuclear grade, and with the amount of tumor necrosis and lymphoid infiltration. The correlation of immunohistochemically determined steroid receptor values with histological characteristics was somewhat better than that of biochemically assessed concentrations.
摘要
通过使用单克隆抗受体抗体的免疫组织化学方法（n = 267）和细胞质类固醇结合测定法（n = 212）对人乳腺癌进行雌激素和孕激素受体评估。肿瘤的雌激素和孕激素受体含量与分化的组织学特征相关，如组织学和核分级，以及与肿瘤坏死和淋巴样浸润的程度相关。免疫组织化学测定的类固醇受体值与组织学特征的相关性略优于生化评估的浓度。
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