雌激素和孕激素受体与乳腺癌组织学分化的相关性

Correlation of estrogen and progesterone receptors with histologic differentiation in mammary carcinoma.

作者信息

McCarty K S, Barton T K, Fetter B F, Woodard B H, Mossler J A, Reeves W, Daly J, Wilkinson W E, McCarty K S

出版信息

Cancer. 1980 Dec 15;46(12 Suppl):2851-8. doi: 10.1002/1097-0142(19801215)46:12+<2851::aid-cncr2820461424>3.0.co;2-k.

DOI:10.1002/1097-0142(19801215)46:12+<2851::aid-cncr2820461424>3.0.co;2-k

Abstract

Using a modification of the histologic grading system of the NSABP, we observed a trend towards higher levels of estrogen (E2R) and progesterone receptor (PR) content in well (grade I) and moderately (grade II) differentiated mammary carcinomas. This relationship between receptor content and histologic grade is enhanced by considering estrogen and progesterone receptor simultaneously. The rank correlation between the quantitative levels of E2R and PR was 0.74 among histologic grade I tumors and 0.64 among histologic grade II tumors. Among the grade III carcinomas, the majority of tumors displayed either a paucity of measurable receptor or a divergence between levels of estrogen versus progesterone receptor (r = 0.19). The use of ultrastructural evaluation of features of differentiation is discussed in the evaluation of grade III tumors and in the evaluation of specific histologic types of mammary carcinoma.

摘要

采用美国国立外科辅助乳腺和肠道项目（NSABP）组织学分级系统的一种改良方法，我们观察到在高分化（I级）和中分化（II级）乳腺癌中，雌激素（E2R）和孕激素受体（PR）含量有升高趋势。同时考虑雌激素和孕激素受体时，受体含量与组织学分级之间的这种关系会增强。在组织学I级肿瘤中，E2R和PR定量水平之间的等级相关性为0.74，在组织学II级肿瘤中为0.64。在III级癌中，大多数肿瘤要么显示可测量受体缺乏，要么雌激素与孕激素受体水平存在差异（r = 0.19）。在III级肿瘤评估以及特定组织学类型乳腺癌评估中，讨论了使用分化特征的超微结构评估。