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高效液相色谱法研究在微处理器控制的高压灭菌器中进行热灭菌的5%葡萄糖溶液的降解情况。

HPLC studies on the degradation profiles of glucose 5% solutions subjected to heat sterilization in a microprocessor-controlled autoclave.

作者信息

Cook A P, MacLeod T M, Appleton J D, Fell A F

机构信息

Area Pharmaceutical Laboratory, Ninewells Hospital, Dundee, U.K.

出版信息

J Clin Pharm Ther. 1989 Jun;14(3):189-95. doi: 10.1111/j.1365-2710.1989.tb00237.x.

DOI:10.1111/j.1365-2710.1989.tb00237.x
PMID:2760117
Abstract

A practically useful relationship between degradation and F0 at various temperatures is given. This may be of value for identifying the most suitable sterilization conditions for a number of glucose products and other pharmaceuticals. It was found that autoclaving at a high temperature to a low final F0 value gave the maximum product integrity.

摘要

给出了不同温度下降解与F0之间切实可用的关系。这对于确定多种葡萄糖产品及其他药品的最合适灭菌条件可能具有价值。研究发现，在高温下进行高压灭菌至较低的最终F0值可使产品完整性达到最大。

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HPLC studies on the degradation profiles of glucose 5% solutions subjected to heat sterilization in a microprocessor-controlled autoclave.高效液相色谱法研究在微处理器控制的高压灭菌器中进行热灭菌的5%葡萄糖溶液的降解情况。
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引用本文的文献

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