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Phase III Randomized Trial of Ipilimumab Plus Etoposide and Platinum Versus Placebo Plus Etoposide and Platinum in Extensive-Stage Small-Cell Lung Cancer.三期随机临床试验：伊匹单抗联合依托泊苷和铂类药物与安慰剂联合依托泊苷和铂类药物治疗广泛期小细胞肺癌。
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Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.克隆性新抗原引发T细胞免疫反应性以及对免疫检查点阻断的敏感性。
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Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.癌症免疫学。突变图谱决定非小细胞肺癌对程序性死亡受体1（PD-1）阻断治疗的敏感性。
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Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.综合性基因组分析鉴定出小细胞肺癌的重要体细胞驱动突变。
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Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial.伊匹单抗联合紫杉醇和卡铂作为广泛期小细胞肺癌的一线治疗：一项随机、双盲、多中心 2 期临床试验的结果。
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The blockade of immune checkpoints in cancer immunotherapy.癌症免疫疗法中的免疫检查点阻断。
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Theory Meets Practice for Immune Checkpoint Blockade in Small-Cell Lung Cancer.

作者信息

Riess Jonathan W, Lara Primo N, Gandara David R

机构信息

Jonathan W. Riess, Primo N. Lara Jr, and David R. Gandara, University of California Davis Comprehensive Cancer Center, Sacramento, CA.

出版信息

J Clin Oncol. 2016 Nov 1;34(31):3717-3718. doi: 10.1200/JCO.2016.69.0040.

DOI:10.1200/JCO.2016.69.0040
PMID:27601544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5477925/
Abstract
摘要