Forde Natalie J, Kanaan Ahmad S, Widomska Joanna, Padmanabhuni Shanmukha S, Nespoli Ester, Alexander John, Rodriguez Arranz Juan I, Fan Siyan, Houssari Rayan, Nawaz Muhammad S, Rizzo Francesca, Pagliaroli Luca, Zilhäo Nuno R, Aranyi Tamas, Barta Csaba, Boeckers Tobias M, Boomsma Dorret I, Buisman Wim R, Buitelaar Jan K, Cath Danielle, Dietrich Andrea, Driessen Nicole, Drineas Petros, Dunlap Michelle, Gerasch Sarah, Glennon Jeffrey, Hengerer Bastian, van den Heuvel Odile A, Jespersgaard Cathrine, Möller Harald E, Müller-Vahl Kirsten R, Openneer Thaïra J C, Poelmans Geert, Pouwels Petra J W, Scharf Jeremiah M, Stefansson Hreinn, Tümer Zeynep, Veltman Dick J, van der Werf Ysbrand D, Hoekstra Pieter J, Ludolph Andrea, Paschou Peristera
Department of Psychiatry, University of Groningen, University Medical Center GroningenGroningen, Netherlands; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical CenterNijmegen, Netherlands.
Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical SchoolHannover, Germany; Max Planck Institute for Human Cognitive and Brain SciencesLeipzig, Germany.
Front Neurosci. 2016 Aug 23;10:384. doi: 10.3389/fnins.2016.00384. eCollection 2016.
Gilles de la Tourette Syndrome (GTS) is characterized by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency, and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared etiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No. 316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex etiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications, and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii) exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii) employing endophenotype-based approaches to understand the shared etiology between GTS, OCD, and ADHD; (iv) establishing a developmental animal model for GTS; (v) gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi) partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and 12 PhD candidates pursue the project. Here, we aim to share the design of an interdisciplinary project, showcasing the potential of large-scale collaborative efforts in the field of GTS. Our ultimate aims are to elucidate the complex etiology and neurobiological underpinnings of GTS, translate research findings into clinical applications, and establish Pan-European infrastructure for the study of GTS and associated disorders.
抽动秽语综合征（GTS）的特征是存在多种运动性和发声性抽动，其强度、频率和严重程度呈波动变化。高达90%的GTS患者伴有共病情况，最常见的是注意力缺陷多动障碍（ADHD）和强迫症（OCD），因此为探索不同疾病之间的共同病因提供了一个极佳的模型。TS-EUROTRAIN（FP7-PEOPLE-2012-ITN，资助编号316978）是一个玛丽居里初始培训网络（http://ts-eurotrain.eu），旨在阐明GTS发病和临床过程的复杂病因，研究GTS及相关疾病的神经生物学基础，将研究成果转化为临床应用，并建立一个泛欧的GTS研究基础设施。这包括以下挑战：（i）组装一个大型基因数据库，以高统计效力评估基因结构；（ii）探索基因-环境相互作用的作用，包括表观遗传现象的影响；（iii）采用基于内表型的方法来理解GTS、OCD和ADHD之间的共同病因；（iv）建立GTS的发育动物模型；（v）通过横断面和纵向神经影像学研究，对GTS的神经生物学机制获得新的见解；（vi）参与外展活动，包括向公众传播有关GTS的科学知识。来自学术界和工业界的15个合作伙伴以及12名博士研究生参与该项目。在此，我们旨在分享一个跨学科项目的设计，展示在GTS领域大规模合作努力的潜力。我们的最终目标是阐明GTS的复杂病因和神经生物学基础，将研究成果转化为临床应用，并建立泛欧的GTS及相关疾病研究基础设施。
