小鼠抗狂犬病单克隆抗体在狂犬病暴露后治疗中的应用。
Use of mouse anti-rabies monoclonal antibodies in postexposure treatment of rabies.
作者信息
Schumacher C L, Dietzschold B, Ertl H C, Niu H S, Rupprecht C E, Koprowski H
机构信息
Wistar Institute, Philadelphia, Pennsylvania 19104.
出版信息
J Clin Invest. 1989 Sep;84(3):971-5. doi: 10.1172/JCI114260.
Abstract
Immunization of mice and hamsters with a cocktail of mouse MAbs specific for rabies virus nucleocapsid protein and glycoprotein protected animals not only when challenged with a lethal dose of rabies virus after immunization, but also in post-exposure situations. Hamsters treated with the MAb cocktail 3 h after virus inoculation were completely protected from lethal rabies virus infection, and 80% of the animals survived when the MAb cocktail was given 36 h after virus challenge. The potential usefulness of this MAb cocktail for the postexposure treatment of human rabies is discussed.
摘要
用针对狂犬病病毒核衣壳蛋白和糖蛋白的小鼠单克隆抗体混合物对小鼠和仓鼠进行免疫，不仅在免疫后用致死剂量的狂犬病病毒攻击时能保护动物，而且在暴露后情况下也能起到保护作用。在病毒接种后3小时用单克隆抗体混合物处理的仓鼠完全免受致死性狂犬病病毒感染，当在病毒攻击后36小时给予单克隆抗体混合物时，80%的动物存活。本文讨论了这种单克隆抗体混合物在人类狂犬病暴露后治疗中的潜在用途。
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本文引用的文献
1
Use of hyperimmune anti-rabies serum concentrates in experimental rabies.
Am J Med. 1950 Apr;8(4):412-20. doi: 10.1016/0002-9343(50)90224-5.
2
3
Antigenic analysis of rabies and Mokola virus from Zimbabwe using monoclonal antibodies.
Dev Biol Stand. 1984;57:199-211.
4
Structural basis of antibody function.
Annu Rev Immunol. 1983;1:87-117. doi: 10.1146/annurev.iy.01.040183.000511.
5
Effects of monoclonal antibody immunotherapy on patients with gastrointestinal adenocarcinoma.
J Biol Response Mod. 1984;3(2):138-50.
6
Effects of monoclonal antibody therapy in patients with chronic lymphocytic leukemia.
Blood. 1984 Nov;64(5):1085-93.
7
Cellular origin and interactions involved in gamma-interferon production induced by OKt3 monoclonal antibody.
J Immunol. 1982 Feb;128(2):585-9.
8
Phase-I clinical trial of monoclonal antibody in treatment of gastrointestinal tumours.
Lancet. 1982 Apr 3;1(8275):762-5. doi: 10.1016/s0140-6736(82)91811-6.
9
Effective protection of monkeys against death from street virus by post-exposure administration of tissue-culture rabies vaccine.
Bull World Health Organ. 1971;45(1):1-11.
10
Laboratory techniques in rabies. Habel test for potency.
Monogr Ser World Health Organ. 1966;23:140-3.
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