用水中产生的非热大气等离子体处理胃癌细胞。
Treatment of gastric cancer cells with nonthermal atmospheric plasma generated in water.
作者信息
Chen Zhitong, Lin Li, Cheng Xiaoqian, Gjika Eda, Keidar Michael
机构信息
Department of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052.
出版信息
Biointerphases. 2016 Sep 7;11(3):031010. doi: 10.1116/1.4962130.
Nonthermal atmospheric plasma (NTAP) can be applied to living tissues and cells as a novel technology for cancer therapy. The authors report on a NTAP argon solution generated in deionized (DI) water for treating human gastric cancer cells (NCI-N87). Our findings show that the plasma generated in DI water with 30-min duration has the strongest effect on apoptosis in precultured human gastric cancer cells. This result can be attributed to the presence of reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced in water during treatment. Furthermore, the data show that the elevated levels of RNS may play a more significant role than ROS in the rate of cell death.
非热大气等离子体（NTAP）作为一种癌症治疗新技术可应用于活组织和细胞。作者报告了一种在去离子（DI）水中产生的用于治疗人胃癌细胞（NCI-N87）的NTAP氩溶液。我们的研究结果表明，持续30分钟在去离子水中产生的等离子体对预培养的人胃癌细胞凋亡的影响最强。这一结果可归因于处理过程中水中产生的活性氧（ROS）和活性氮（RNS）。此外，数据表明，RNS水平的升高在细胞死亡率方面可能比ROS发挥更重要的作用。
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