Mitra Sarmistha, Nguyen Linh Nhat, Akter Mahmuda, Park Gyungsoon, Choi Eun Ha, Kaushik Nagendra Kumar
Plasma Bioscience Research Center, Applied Plasma Medicine Center, Department of Plasma Bio-display, Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Korea.
Cancers (Basel). 2019 Jul 22;11(7):1030. doi: 10.3390/cancers11071030.
For the last few decades, while significant improvements have been achieved in cancer therapy, this family of diseases is still considered one of the deadliest threats to human health. Thus, there is an urgent need to find novel strategies in order to tackle this vital medical issue. One of the most pivotal causes of cancer initiation is the presence of reactive oxygen species (ROS) inside the body. Interestingly, on the other hand, high doses of ROS possess the capability to damage malignant cells. Moreover, several important intracellular mechanisms occur during the production of ROS. For these reasons, inducing ROS inside the biological system by utilizing external physical or chemical methods is a promising approach to inhibit the growth of cancer cells. Beside conventional technologies, cold atmospheric plasmas are now receiving much attention as an emerging therapeutic tool for cancer treatment due to their unique biophysical behavior, including the ability to generate considerable amounts of ROS. This review summarizes the important mechanisms of ROS generated by chemical, physical, and plasma approaches. We also emphasize the biological effects and cancer inhibition capabilities of ROS.
在过去几十年里，尽管癌症治疗取得了显著进展，但这类疾病仍然被认为是对人类健康最致命的威胁之一。因此，迫切需要找到新的策略来解决这一重大医学问题。癌症发生的最关键原因之一是体内存在活性氧（ROS）。有趣的是，另一方面，高剂量的ROS具有损伤恶性细胞的能力。此外，在ROS产生过程中会发生几种重要的细胞内机制。基于这些原因，通过利用外部物理或化学方法在生物系统中诱导ROS是一种抑制癌细胞生长的有前景的方法。除了传统技术外，冷大气等离子体由于其独特的生物物理行为，包括产生大量ROS的能力，作为一种新兴的癌症治疗工具正受到广泛关注。本综述总结了化学、物理和等离子体方法产生ROS的重要机制。我们还强调了ROS的生物学效应和癌症抑制能力。
