Young Andrea S, Arnold L Eugene, Wolfson Hannah L, Fristad Mary A
Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH, USA.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5300 Alpha Commons Drive, 4th Floor, Baltimore, MD, 21224, USA.
J Abnorm Child Psychol. 2017 Jul;45(5):1025-1037. doi: 10.1007/s10802-016-0203-3.
This pilot randomized controlled trial (RCT) investigated benefits of omega-3 fatty acid supplementation and Individual-Family Psychoeducational Psychotherapy (PEP; a family-focused, cognitive-behavioral therapy) for behavior problems among youth with depression. Participants aged 7-14 with DSM-IV-TR depressive disorders (N = 72; 56.9 % male) were randomized to 1 of 4 treatment conditions: PEP + omega-3, PEP monotherapy (with pill placebo), omega-3 monotherapy, or placebo (without active intervention). At screen, baseline, and 2, 4, 6, 9, and 12 weeks post-baseline, parents completed the SNAP-IV, which assesses attention-deficit/hyperactivity disorder symptoms, oppositional defiant disorder symptoms, and overall behavior problems. At screen, baseline (randomization), 6 and 12 weeks, parents completed the Eyberg Child Behavior Inventory (ECBI), which includes Intensity and Problem scales for child behavior problems. Youth who had a completed SNAP-IV or ECBI for at least two assessments during treatment (n = 48 and 38, respectively) were included in analyses of the respective outcome. ClinicalTrials.gov.:NCT01341925. Linear mixed effects models indicated a significant effect of combined PEP + omega-3 on SNAP-IV Total (p = 0.022, d = 0.80) and Hyperactivity/Impulsivity trajectories (p = 0.008, d = 0.80), such that youth in the combined group saw greater behavioral improvement than those receiving only placebo. Similarly, youth in combined treatment had more favorable ECBI Intensity trajectories than youth who received no active treatment (p = 0.012, d = 1.07). Results from this pilot RCT suggest that combined PEP + omega-3 is a promising treatment for co-occurring behavior symptoms in youth with depression.
这项初步随机对照试验（RCT）研究了补充ω-3脂肪酸和个体-家庭心理教育心理治疗（PEP；一种以家庭为重点的认知行为疗法）对患有抑郁症的青少年行为问题的益处。年龄在7至14岁、患有DSM-IV-TR抑郁症的参与者（N = 72；56.9%为男性）被随机分配到4种治疗条件中的一种：PEP + ω-3、PEP单一疗法（服用药丸安慰剂）、ω-3单一疗法或安慰剂（无积极干预）。在筛查时、基线时以及基线后2周、4周、6周、9周和12周，家长完成了SNAP-IV，该量表评估注意力缺陷/多动障碍症状、对立违抗障碍症状和总体行为问题。在筛查时、基线（随机分组）、6周和12周，家长完成了Eyberg儿童行为量表（ECBI），该量表包括儿童行为问题的强度和问题量表。在治疗期间至少有两次评估完成了SNAP-IV或ECBI的青少年（分别为n = 48和38）被纳入各自结果的分析。ClinicalTrials.gov：NCT01341925。线性混合效应模型表明，联合使用PEP + ω-3对SNAP-IV总分（p = 0.022，d = 0.80）和多动/冲动轨迹（p = 0.008，d = 0.80）有显著影响，因此联合组的青少年在行为改善方面比仅接受安慰剂的青少年更明显。同样，联合治疗组的青少年在ECBI强度轨迹方面比未接受积极治疗的青少年更有利（p = 0.012，d = 1.07）。这项初步RCT的结果表明，联合使用PEP + ω-3是治疗患有抑郁症的青少年并发行为症状的一种有前景的疗法。
