Otsuka K, Kawakami T, Saito H, Watanabe H
Department of Medicine, Tokyo Women's Medical College, Daini Hospital, Ku, Japan.
J Electrocardiol. 1989 Jul;22(3):235-40. doi: 10.1016/0022-0736(89)90034-4.
The relationship between rapid eye movement (REM) phasic events and bradyarrhythmia was investigated in five male Wistar rats. ECGs, EEGs (frontal cortex and dorsal hippocampus), and electrooculograms were monitored continuously for 6 days. Sleep states were classified as alertness, slow-wave sleep, or paradoxical sleep, and the frequency of the REM burst was measured to evaluate the REM density. Bradyarrhythmias, such as SA block or AV block, were observed in each rat and were divided into two groups: group A, bradyarrhythmias with a duration greater than 5 sec; and group B, duration less than 5 sec. For a period of 33 days, the five rats showed alertness, slow-wave sleep, and paradoxical sleep 6,481, 6,483, and 1,523 times; bradyarrhythmia incidents in each sleep stage were 0.35%, 0.03%, and 22.4%, respectively. The incidence of bradyarrhythmia episodes increased with REM density, and 78.5% of the episodes appeared related to the REM bursts. The latency between the REM bursts and bradyarrhythmia was as follows: type A bradyarrhythmias, 2.17 +/- 0.41 sec; type B, 3.78 +/- 0.63 sec. These results suggest close association of bradyarrhythmia occurrence with REM phasic events.
在五只雄性Wistar大鼠中研究了快速眼动（REM）相位事件与缓慢性心律失常之间的关系。连续6天监测心电图、脑电图（额叶皮质和背侧海马体）和眼电图。睡眠状态分为警觉、慢波睡眠或异相睡眠，并测量REM爆发频率以评估REM密度。在每只大鼠中观察到缓慢性心律失常，如窦房阻滞或房室阻滞，并分为两组：A组，持续时间大于5秒的缓慢性心律失常；B组，持续时间小于5秒。在33天的时间里，这五只大鼠出现警觉、慢波睡眠和异相睡眠的次数分别为6481次、6483次和1523次；每个睡眠阶段的缓慢性心律失常事件发生率分别为0.35%、0.03%和22.4%。缓慢性心律失常发作的发生率随REM密度增加，且78.5%的发作似乎与REM爆发有关。REM爆发与缓慢性心律失常之间的潜伏期如下：A型缓慢性心律失常为2.17±0.41秒；B型为3.78±0.63秒。这些结果表明缓慢性心律失常的发生与REM相位事件密切相关。
