Wetzel F T, Panjabi M M, Pelker R R
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06510.
J Orthop Res. 1989;7(5):728-31. doi: 10.1002/jor.1100070514.
There are numerous clinical and biomechanical criteria for determination of acute spinal instability. No data, however, exist on the biomechanical behavior of the injured, untreated spine during the healing period. Using a rabbit model, this study was designed to quantify changes in the mechanical properties of the injured spine over time. Sixteen rabbits were assigned to four injury groups: Injury 1 (C4-5 supra/intraspinous ligament transection), Injury 2 (C4 laminectomy), or Injury 3 (C4 laminectomy, plus bilateral facet capsular ligament transection). The fourth injury group was Sham (posterior exposure of C4-5, no spinal injury). Preinjury range of motion was determined by standardized flexion-extension radiographs on all animals. Postinjury flexion-extension radiographs were taken at 4, 8, and 12 weeks. At the end of 12 weeks, animals were killed. Mean range of motion at C4-5 for all injury groups decreased from preinjury values. The greatest decrease was for the most severe injury. At 8 weeks, the range of motion for this injury was less than half of the preinjury level and increased to 62% of the preinjury level at 12 weeks.
有许多用于判定急性脊柱不稳的临床和生物力学标准。然而，尚无关于受伤且未经治疗的脊柱在愈合期生物力学行为的数据。本研究采用兔模型，旨在量化受伤脊柱力学性能随时间的变化。16只兔子被分为四个损伤组：损伤1组（C4 - 5棘上/棘间韧带横断）、损伤2组（C4椎板切除术）或损伤3组（C4椎板切除术加双侧关节囊韧带横断）。第四组为假手术组（C4 - 5后路暴露，无脊柱损伤）。通过对所有动物进行标准化屈伸位X线片来确定伤前活动范围。伤后分别在4周、8周和12周拍摄屈伸位X线片。在12周结束时，处死动物。所有损伤组C4 - 5的平均活动范围均较伤前值减小。最严重损伤组的减小幅度最大。在8周时，该损伤组的活动范围小于伤前水平的一半，在12周时增加至伤前水平的62%。
