Berner B, Juang R H, Mazzenga G C
CIBA-GEIGY Corporation, Ardsley, N.Y. 10502.
J Pharm Sci. 1989 Jun;78(6):472-6. doi: 10.1002/jps.2600780611.
Sorption of ethanol and water into stratum corneum, delipidized stratum corneum, and triolein as a simple model lipid was investigated. Optima in ethanol sorption and flux are related to dehydration of keratins. There was no optimum for solubility in triolein; a linear cosolvency is observed with ethanol:triolein mixtures. A model is proposed which qualitatively predicts the key features of ethanol-enhanced skin permeation on the basis of these solubility phenomena and a constant diffusion coefficient.
研究了乙醇和水在角质层、脱脂角质层以及作为简单模型脂质的三油酸甘油酯中的吸附情况。乙醇吸附和通量的最优值与角蛋白的脱水有关。在三油酸甘油酯中的溶解度没有最优值；乙醇与三油酸甘油酯混合物呈现线性助溶现象。基于这些溶解现象和恒定的扩散系数，提出了一个模型，该模型定性地预测了乙醇增强皮肤渗透的关键特征。
