一名患有常见可变免疫缺陷患者的早发性类固醇诱导后囊下白内障：病例报告及文献综述
Early onset steroid induced posterior subcapsular cataract in a patient with common variable immunodeficiency: case reports and review of literature.
作者信息
Marefat H, Abolhassani H, Ghareje Daghi M, Azizi G, Aghamohammadi A
机构信息
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden.
出版信息
Eur Ann Allergy Clin Immunol. 2016 Sep;48(5):197-201.
Purpose. To report early onset steroid induced posterior subcapsular cataract in a case of common variable immunodeficiency. Methods. Case report. Results. Here we report a 14-yearold male of steroid induced bilateral posterior subcapsular cataract in a common variable immunodeficiency patient with damaging mutations in Glutathione reductase gene, leading to hypersensitivity of patient to glucocorticoid (GC) products. Conclusions. In order to reduce the ocular side effects of the GCs there are some advisements, including a complete history, regular examination, GC should be prescribed in minimal dosage and minimal course, and as possible GC-sparing drugs should always be considered.
目的。报告一例常见可变免疫缺陷患者中早期发生的类固醇诱导的后囊下白内障。方法。病例报告。结果。我们在此报告一名14岁男性，在一名常见可变免疫缺陷患者中发生类固醇诱导的双侧后囊下白内障，该患者谷胱甘肽还原酶基因存在破坏性突变，导致患者对糖皮质激素（GC）产品过敏。结论。为减少GC的眼部副作用，有一些建议，包括详细的病史、定期检查，应以最小剂量和最短疗程开具GC，并应始终考虑尽可能使用GC替代药物。
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