Sahu Ashok, Gupta Trapti, Kavishwar Arvind, Singh R K
Associate Professor.
Asst. Professor, Department of Biochemistry, NSCB Medical College, Jabalpur, Madhya Pradesh.
J Assoc Physicians India. 2015 Oct;63(10):37-40.
Atherosclerosis is associated with increased inflammatory activity and risk of vascular disease. However, the factors that promote inflammation are not apparently clear. In the present study we aimed to evaluate levels of homocysteine in comparison with other markers including inflammatory risk predictor of cardiovascular disease.
A total of 200 patients were included in the study, of these 100 were angiographically proven cardiovascular disease patients and 100 were not suffering from any cardiovascular disease. Levels of homocysteine, hs-CRP, lipoprotein(a), HbA1c and blood lipid were measured along with anthropometric and demographic parameters.
Levels of homocysteine and other markers were significantly increased in diseased group in comparisons to control.
There is a very high sensitivity, specificity, and accuracy with 89% positive predictive value and 39.48 odds ratio for homocysteine in cardiovascular patients when compared to other risk factors.
动脉粥样硬化与炎症活动增加及血管疾病风险相关。然而，促进炎症的因素尚不明确。在本研究中，我们旨在评估同型半胱氨酸水平，并与其他标志物（包括心血管疾病炎症风险预测指标）进行比较。
本研究共纳入200例患者，其中100例经血管造影证实患有心血管疾病，100例未患任何心血管疾病。测量了同型半胱氨酸、高敏C反应蛋白、脂蛋白(a)、糖化血红蛋白和血脂水平，以及人体测量和人口统计学参数。
与对照组相比，患病组的同型半胱氨酸和其他标志物水平显著升高。
与其他风险因素相比，同型半胱氨酸在心血管疾病患者中具有非常高的敏感性、特异性和准确性，阳性预测值为89%，优势比为39.48。
