Sahu Ashok, Gupta Trapti, Kavishwar Arvind, Singh R K
Ukr Biochem J. 2016 Mar-Apr;88(2):35-44. doi: 10.15407/ubj88.02.035.
It is known that inflammation has a role in the pathogenesis of cardiovascular diseases; measurement of inflammatory markers improves the risk prediction of cardiovascular diseases. Hyperhomocysteinemia has been correlated with the occurrence of blood clots, heart attacks and strokes; though it is unclear whether hyperhomocysteinemia is an independent risk factor for these conditions. In the present study, we aimed to evaluate the role of homocysteine in type 2 diabetes patients with cardiovascular disease in a population of Madhya Pradesh India. Total 100 type 2 diabetes patients were included in the study, of these 50 had angiographically proven cardiovascular disease and 50 had no evidence of it. High sensitivity C-reactive protein, fibrinogen, and lipoprotein (a) were measured in serum. Homocysteine, blood glucose in plasma, erythrocyte sedimentation rate, glycated haemoglobin were measured in whole blood. A albumin excretion rate, creatinine clearance rate were measured in the urine sample for renal function. It was shown that, levels of homocysteine and other inflammatory markers were elevated significantly in the group II (n = 50). A correlation between hyperhomocysteinemia and inflammatory markers in patients with impaired renal function was observed. It was concluded that impairment of renal function is a key factor that affects homocysteine level.
已知炎症在心血管疾病的发病机制中起作用；炎症标志物的测量可改善心血管疾病的风险预测。高同型半胱氨酸血症与血栓形成、心脏病发作和中风的发生相关；尽管尚不清楚高同型半胱氨酸血症是否是这些病症的独立危险因素。在本研究中，我们旨在评估在印度中央邦人群中，同型半胱氨酸在患有心血管疾病的2型糖尿病患者中的作用。该研究共纳入100例2型糖尿病患者，其中50例经血管造影证实患有心血管疾病，50例无心血管疾病证据。检测血清中的高敏C反应蛋白、纤维蛋白原和脂蛋白(a)。检测全血中的同型半胱氨酸、血浆血糖、红细胞沉降率、糖化血红蛋白。检测尿样中的白蛋白排泄率、肌酐清除率以评估肾功能。结果显示，第二组（n = 50）中的同型半胱氨酸和其他炎症标志物水平显著升高。观察到肾功能受损患者的高同型半胱氨酸血症与炎症标志物之间存在相关性。得出的结论是，肾功能损害是影响同型半胱氨酸水平的关键因素。
