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胰腺与糖尿病:器官与疾病之间的关系

Pancreas and Diabetes Mellitus: The Relationship between the Organ and the Disease.

作者信息

Menon Saumya, Rajesh Gopalakrishna, Balakrishnan Vallath

机构信息

Department of Gastroenterology, Amrita Institute of Medical Sciences, Kochi, Kerala.

出版信息

J Assoc Physicians India. 2015 Oct;63(10):51-8.

PMID:27608692
Abstract

Diabetes mellitus has been a fascinating disease from the dawn of medical history. The first breakthrough in its treatment came in 1922, with the discovery of insulin which was extracted from the pancreas of a dog. Even earlier, a relationship between pancreas and diabetes mellitus had been suspected by medical scientists. However, the study of diabetes mellitus is much more than its relationship with the pancreas. On the other hand the pancreas has been known to be a very reclusive organ that is hidden away from physicians and surgeons for centuries. In recent times, it has become more accessible and has yielded some of its secrets. The relationship between the pancreas and diabetes mellitus is a story full of complexities and surprises. This article attempts to reveal some of the important events and persons in the story and the controversies surrounding them.

摘要

从医学史开端起,糖尿病就一直是一种引人入胜的疾病。其治疗的首个突破出现在1922年,当时发现了从狗的胰腺中提取的胰岛素。甚至更早之前,医学科学家就怀疑胰腺与糖尿病之间存在关联。然而,对糖尿病的研究远不止于其与胰腺的关系。另一方面,人们已知胰腺是一个非常难以捉摸的器官,几个世纪以来一直躲避着内科医生和外科医生。近年来,它变得更容易被研究,并揭示了一些秘密。胰腺与糖尿病之间的关系是一个充满复杂性和惊喜的故事。本文试图揭示这个故事中的一些重要事件、人物以及围绕他们的争议。

相似文献

1
Pancreas and Diabetes Mellitus: The Relationship between the Organ and the Disease.胰腺与糖尿病:器官与疾病之间的关系
J Assoc Physicians India. 2015 Oct;63(10):51-8.
2
A history of diabetes: from antiquity to discovering insulin.糖尿病史:从古代到胰岛素的发现
Br J Nurs. 2003;12(18):1091-5. doi: 10.12968/bjon.2003.12.18.11775.
3
[The cultural history of the discovery of insulin].[胰岛素发现的文化史]
Lege Artis Med. 2014 Apr;24(4):222-8.
4
The pancreas.
R I Med. 1994 Apr;77(4):97-9.
5
[A century of research on the islands of Langerhans. Stage in the development of diabetes mellitus research].[对胰岛的百年研究。糖尿病研究发展阶段]
Anat Anz. 1975;137(5):470-8.
6
Diabetes through the ages: a salute to insulin.穿越岁月的糖尿病:向胰岛素致敬。
S Afr Med J. 1972 Sep 23;46(38):1394-400.
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Milestones in the history of diabetes--a brief survey.糖尿病历史上的里程碑——简要概述。
S Afr Med J. 1970 Oct 10;44(40):1158-61.
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History of the pancreas.胰腺的病史。
Am J Surg. 1983 Nov;146(5):539-50. doi: 10.1016/0002-9610(83)90286-6.
9
[Historical evolution of knowledge of diabetes mellitus before the discovery of insulin. Review].[胰岛素发现之前糖尿病知识的历史演变。综述]
Vnitr Lek. 1972 Jan;18(1):67-72.
10
[Diabetes and the pancreas before diabetes].[糖尿病与糖尿病前期的胰腺]
Ann Osp Maria Vittoria Torino. 1977 Jan-Jun;20(1-6):93-129.

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1
Diabetes: discovery of insulin, genetic, epigenetic and viral infection mediated regulation.糖尿病:胰岛素的发现、遗传、表观遗传及病毒感染介导的调控
Nucleus (Calcutta). 2022;65(2):283-297. doi: 10.1007/s13237-021-00376-x. Epub 2021 Oct 5.
2
Endoplasmic reticulum stress as the basis of obesity and metabolic diseases: focus on adipose tissue, liver, and pancreas.内质网应激作为肥胖和代谢性疾病的基础:聚焦于脂肪组织、肝脏和胰腺。
Eur J Nutr. 2021 Sep;60(6):2949-2960. doi: 10.1007/s00394-021-02542-y. Epub 2021 Mar 19.