Koh K T, Teh C L, Cheah C K, Ling G R, Yong M C, Hong H C, Gun S C
Department of Medicine, Miri Hospital, Sarawak.
Reumatismo. 2016 Sep 9;68(2):90-6. doi: 10.4081/reumatismo.2016.872.
The objective of this study was to compare the tolerability of methotrexate in two different regimes of folic acid (FA) supplementation in rheumatoid arthritis (RA). We performed a multicenter, cross-sectional observational cohort study on 240 RA patients with 120 patients each in 5 mg of FA weekly and 30 mg of FA weekly supplementation. There were no significant differences for side effects (14.2 versus 22.5%, P=0.523) and discontinuation of methotrexate (3.6 versus 13.3%, P=0.085). RA patients given 5 mg of FA weekly supplementation had a lower disease activity score 28 compared to 30 mg of FA weekly supplementation [3.44 (1.10) versus 3.85 (1.40), P=0.014]. FA supplementation of 5 mg per week and 30 mg per week was associated with similar tolerability of methotrexate in RA patients.
本研究的目的是比较类风湿关节炎（RA）患者在两种不同叶酸（FA）补充方案下甲氨蝶呤的耐受性。我们对240例RA患者进行了一项多中心横断面观察性队列研究，每组120例，分别接受每周5 mg FA补充和每周30 mg FA补充。副作用（14.2%对22.5%，P = 0.523）和甲氨蝶呤停药率（3.6%对13.3%，P = 0.085）无显著差异。与每周补充30 mg FA的RA患者相比，每周补充5 mg FA的患者疾病活动度评分28更低[3.44（1.10）对3.85（1.40），P = 0.014]。每周补充5 mg和30 mg FA与RA患者中甲氨蝶呤的相似耐受性相关。
