Nara P, Hatch W, Kessler J, Kelliher J, Carter S
Laboratory of Tumor Cell Biology, National Cancer Institute, Frederick, MD.
J Med Primatol. 1989;18(3-4):343-55.
Human immunodeficiency virus (HIV)-1 IIIB infection of chimpanzees leads to a compartmentalized, nonpathogenic in vivo and in vitro relationship with the virus. The absence of an acquired immunodeficiency syndrome (AIDS)-like disease in over 100 chimpanzees persistently infected may be related to some or all of the findings reported here. Further characterizing these possible host adapative mechanisms may be critical in both understanding pathogenesis, as well as elucidating novel mechanisms for therapeutic and/or the preventive strategies for AIDS in humans.
黑猩猩感染人类免疫缺陷病毒1型（HIV-1）IIIB毒株后，在体内和体外均与该病毒形成一种分隔的、非致病性的关系。超过100只持续感染的黑猩猩未出现类似获得性免疫缺陷综合征（AIDS）的疾病，这可能与本文报道的部分或全部发现有关。进一步阐明这些可能的宿主适应性机制，对于理解发病机制以及阐明治疗和/或预防人类AIDS的新机制可能至关重要。
