Brea Angel, Millán Jesús, Ascaso Juan F, Blasco Mariano, Díaz Angel, González-Santos Pedro, Hernández-Mijares Antonio, Mantilla Teresa, Pedro-Botet Juan C, Pintó Xavier
Grupo de Trabajo sobre la Dislipemia Aterogénica de la Sociedad Española de Arteriosclerosis, España; Unidad de Lípidos, Servicio de Medicina Interna, Hospital San Pedro, Logroño, España.
Grupo de Trabajo sobre la Dislipemia Aterogénica de la Sociedad Española de Arteriosclerosis, España; Unidad de Lípidos, Servicio de Medicina Interna, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, España.
Clin Investig Arterioscler. 2016 Nov-Dec;28(6):295-301. doi: 10.1016/j.arteri.2016.06.001. Epub 2016 Sep 5.
To control lipid factors risk, beyond proper management of LDL cholesterol according to individual risk, detection and treatment of atherogenic dyslipidemia and abnormal levels of triglycerides or HDL cholesterol it should be considered for address a global cardiovascular protection, both in primary and secondary prevention. In this sense, these recommendations collect data on efficacy and safety about the combination statin with fibrates, often necessary for total control of dyslipidemia, particularly in patients with metabolic disorders such as diabetes mellitus, metabolic syndrome or visceral obesity. Reference to control and monitoring of treatment is also done, as well as benefits of fenofibrate not linked directly to their lipid-lowering effect.
为控制脂质因素风险,除根据个体风险适当管理低密度脂蛋白胆固醇外,还应考虑检测和治疗致动脉粥样硬化性血脂异常以及甘油三酯或高密度脂蛋白胆固醇水平异常,以实现一级和二级预防中的全面心血管保护。从这个意义上说,这些建议收集了有关他汀类药物与贝特类药物联合使用的疗效和安全性数据,这对于全面控制血脂异常通常是必要的,尤其是在患有糖尿病、代谢综合征或内脏肥胖等代谢紊乱的患者中。还提到了治疗的控制和监测,以及非诺贝特的益处,这些益处并非直接与其降脂作用相关。