Yin Teng-Fei, Wang Min, Qing Ying, Lin Ying-Min, Wu Dong
Teng-Fei Yin, Min Wang, Ying Qing, Department of Gastroenterology, Geriatrics, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.
World J Gastroenterol. 2016 Aug 21;22(31):7058-68. doi: 10.3748/wjg.v22.i31.7058.
Colorectal cancer (CRC) is a type of cancer with high morbidity and mortality rates worldwide and has become a global health problem. The conventional radiotherapy and chemotherapy regimen for CRC not only has a low cure rate but also causes side effects. Many studies have shown that adequate intake of fruits and vegetables in the diet may have a protective effect on CRC occurrence, possibly due to the special biological protective effect of the phytochemicals in these foods. Numerous in vitro and in vivo studies have demonstrated that phytochemicals play strong antioxidant, anti-inflammatory and anti-cancer roles by regulating specific signaling pathways and molecular markers to inhibit the occurrence and development of CRC. This review summarizes the progress on CRC prevention using the phytochemicals sulforaphane, curcumin and resveratrol, and elaborates on the specific underlying mechanisms. Thus, we believe that phytochemicals might provide a novel therapeutic approach for CRC prevention, but future clinical studies are needed to confirm the specific preventive effect of phytochemicals on cancer.
结直肠癌（CRC）是一种在全球范围内发病率和死亡率都很高的癌症，已成为一个全球性的健康问题。CRC的传统放疗和化疗方案不仅治愈率低，而且会引起副作用。许多研究表明，饮食中充分摄入水果和蔬菜可能对CRC的发生具有保护作用，这可能是由于这些食物中的植物化学物质具有特殊的生物保护作用。大量的体外和体内研究表明，植物化学物质通过调节特定的信号通路和分子标志物来发挥强大的抗氧化、抗炎和抗癌作用，从而抑制CRC的发生和发展。本综述总结了使用植物化学物质萝卜硫素、姜黄素和白藜芦醇预防CRC的研究进展，并阐述了其具体的潜在机制。因此，我们认为植物化学物质可能为CRC预防提供一种新的治疗方法，但未来还需要临床研究来证实植物化学物质对癌症的具体预防效果。
