结直肠癌：姜黄素和白藜芦醇的化学预防作用。
Colorectal cancer: chemopreventive role of curcumin and resveratrol.
机构信息
Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan 48201, USA.
出版信息
Nutr Cancer. 2010;62(7):958-67. doi: 10.1080/01635581.2010.510259.
Abstract
Colorectal cancer (CRC) is a second leading cause of cancer deaths in the Western world. Currently there is no effective treatment except resection at a very early stage with or without chemotherapy. Of various epithelial cancers, CRC in particular has a potential for prevention, since most cancers follow the adenoma-carcinoma sequence, and the interval between detection of an adenoma and its progression to carcinoma is usually about a decade. However no effective chemopreventive agent except COX-2 inhibitors, limited in their scope due to cardiovascular side effects, have shown promise in reducing adenoma recurrence. To this end, natural agents that can target important carcinogenic pathways without demonstrating discernible adverse effects would serve as ideal chemoprevention agents. In this review, we discuss merits of two such naturally occurring dietary agents-curcumin and resveratrol-for chemoprevention of CRC.
摘要
结直肠癌（CRC）是西方世界癌症死亡的第二大主要原因。目前，除了在非常早期阶段进行切除外，没有有效的治疗方法，无论是否进行化疗。在各种上皮癌中，CRC 特别具有预防的潜力，因为大多数癌症都遵循腺瘤-癌序列，并且从检测到腺瘤到其进展为癌的间隔通常约为十年。然而，除了 COX-2 抑制剂外，没有有效的化学预防剂，由于心血管副作用，其范围有限，显示出减少腺瘤复发的希望。为此，能够靶向重要致癌途径而不表现出明显不良反应的天然剂将作为理想的化学预防剂。在这篇综述中，我们讨论了两种天然存在的饮食剂——姜黄素和白藜芦醇——用于 CRC 化学预防的优点。
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本文引用的文献
1
Curcumin synergizes with resveratrol to inhibit colon cancer.姜黄素与白藜芦醇协同抑制结肠癌。
Nutr Cancer. 2009;61(4):544-53. doi: 10.1080/01635580902752262.
2
Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R.姜黄素通过调节表皮生长因子受体（EGFR）和胰岛素样生长因子-1受体（IGF-1R）增强5-氟尿嘧啶和奥沙利铂对结肠癌细胞生长抑制的作用。
Int J Cancer. 2008 Jan 15;122(2):267-73. doi: 10.1002/ijc.23097.
3
Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells.白藜芦醇在人结肠癌细胞中诱导促凋亡内质网应激。
Oncol Rep. 2007 Nov;18(5):1269-73.
4
Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy.聚合物纳米颗粒包裹的姜黄素（“纳米姜黄素”）：一种人类癌症治疗的新策略。
J Nanobiotechnology. 2007 Apr 17;5:3. doi: 10.1186/1477-3155-5-3.
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Mol Cancer Ther. 2007 Apr;6(4):1276-82. doi: 10.1158/1535-7163.MCT-06-0556.
6
Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity.姜黄素诱导人白血病细胞HL-60凋亡与端粒酶活性抑制有关。
Mol Cell Biochem. 2007 Mar;297(1-2):31-9. doi: 10.1007/s11010-006-9319-z. Epub 2006 Nov 10.
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Expert Opin Investig Drugs. 2006 Oct;15(10):1191-200. doi: 10.1517/13543784.15.10.1191.
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J Exp Clin Cancer Res. 2006 Jun;25(2):189-93.
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Br J Nutr. 2006 Jul;96(1):145-53. doi: 10.1079/bjn20061789.
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