Hani Umme, Shivakumar H G, Osmani Riyaz Ali M, Srivastava Atul, Kumar Varma Naga Sravan
Department of Pharmaceutics, JSS College of Pharmacy, JSS University, SriShivarathreeshwara Nagar, Mysore-570 015, Karnataka, India.
Iran J Pharm Res. 2016 Winter;15(1):23-34.
The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesive polymers like xanthan gum, guar gum and HPMC. Curcumin tablets were characterized by studies of friability, hardness, hydration, DSC, mucoadhesion, In-vitro release and antifungal activity. DSC and FT-IR data indicate there was no interaction between the drug and the excipients and also polymer concentration has some effects on melting point of curcumin. Formulation F3 showed the best results in terms of swelling and mucoadhesion together with prolonged drug release. The antifungal activity of the Curcumin tablet has demonstrated a significant effect against Candida albicans. Hence, the study indicates the possible and effective use of curcumin bioadhesive monolithic vaginal tablet for vaginal candidiasis as a promising natural antifungal treatment.
本研究旨在研制一种治疗阴道念珠菌病的天然片剂，以消除现有抗真菌药物引起的副作用。与现有的唑类抗真菌药物相比，姜黄素具有良好的抗真菌活性。通过直接压片法，以不同比例的生物粘附聚合物如黄原胶、瓜尔胶和羟丙基甲基纤维素制备了生物粘附性姜黄素阴道片。通过脆碎度、硬度、水化、差示扫描量热法（DSC）、粘膜粘附性、体外释放和抗真菌活性研究对姜黄素片进行了表征。DSC和傅里叶变换红外光谱（FT-IR）数据表明药物与辅料之间没有相互作用，而且聚合物浓度对姜黄素的熔点有一定影响。制剂F3在溶胀和粘膜粘附以及延长药物释放方面显示出最佳效果。姜黄素片的抗真菌活性已证明对白色念珠菌有显著作用。因此，该研究表明姜黄素生物粘附性整体阴道片作为一种有前景的天然抗真菌治疗方法，对阴道念珠菌病具有潜在的有效应用价值。
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