Abidin Ismin Zainol, Murphy Emma J, Fehrenbach Gustavo Waltzer, Rezoagli Emanuele, Gately Noel, Major Ian
PRISM Research Institute, Technological University of the Shannon: Midlands Midwest, Athlone Campus, Westmeath - Ireland.
LIFE-Health and Biosciences Research Institute, Technological University of the Shannon, Midwest Campus, Limerick - Ireland.
Drug Target Insights. 2023 Jan 16;17:5-30. doi: 10.33393/dti.2023.2477. eCollection 2023 Jan-Dec.
Drug administration through the vaginal tract is one of the oldest modalities of pharmacotherapy, and it is also one of the most explored. Since the vaginal cavity has a wide surface area, a plentiful blood supply, and a complex network of blood arteries, it can evade hepatic first-pass metabolism and obtain high local drug concentrations. Vaginal pills look to be a good dose form since they are simple to use, portable, and can easily deliver the required amount of medicine. Vaginal formulations, on the other hand, are vulnerable to rapid expulsion due to the vaginal tract’s self-cleaning action, which reduces the formulation’s efficiency. Currently, there is an increasing amount of focus on mucoadhesive vaginal formulation research and development to fix the formulation at the place where the medicine can be released and/or absorbed. This article examines all of the strategies used by researchers to develop a mucoadhesive vaginal tablet that is safe, effective, and comfortable for the user.
经阴道给药是最古老的药物治疗方式之一，也是研究最为深入的方式之一。由于阴道腔表面积大、血液供应丰富且有复杂的血管网络，它可以避免肝脏首过代谢并获得较高的局部药物浓度。阴道丸剂似乎是一种很好的剂型，因为它们使用简单、便于携带，并且可以轻松递送所需剂量的药物。另一方面，由于阴道的自我清洁作用，阴道制剂容易被快速排出，从而降低了制剂的有效性。目前，越来越多的研究集中在粘膜粘附性阴道制剂的研发上，以便将制剂固定在药物能够释放和/或吸收的部位。本文探讨了研究人员为开发一种对使用者安全、有效且舒适的粘膜粘附性阴道片所采用的所有策略。
