Olai H, Thornéus G, Watson H, Macleod M R, Friberg H, Rhodes J, Nielsen N, Cronberg T, Deierborg T
Department of Experimental Medical Science Experimental Neuroinflammation Laboratory Lund Sweden.
Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK.
Evid Based Preclin Med. 2016 Aug;3(1):e00014. doi: 10.1002/ebm2.14. Epub 2016 May 3.
Targeted temperature management (TTM) of 32-34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 showed benefits to survival and neurological outcome. Recently, this treatment has been challenged by another clinical trial showing no difference in outcome between TTM of 33 °C and 36 °C. This protocol describes the methodology for a meta-analysis detailing temperature-reducing interventions to treat global ischaemia in animal models. By combining relevant data sets in the literature, we will explore the experimental evidence for TTM. Our aims are to explain possible translational gaps and provide methodological considerations for future experimental research and clinical trials.
自2002年的临床试验表明目标体温管理（TTM）对生存和神经功能预后有益以来，32-34°C的目标体温管理一直是院外心脏骤停的标准治疗方法。最近，另一项临床试验对这种治疗方法提出了挑战，该试验表明33°C和36°C的TTM在预后方面没有差异。本方案描述了一项荟萃分析的方法，详细说明了在动物模型中治疗全脑缺血的降温干预措施。通过整合文献中的相关数据集，我们将探索TTM的实验证据。我们的目的是解释可能存在的转化差距，并为未来的实验研究和临床试验提供方法学上的考虑。
