瘤胃中NQO1、RGS5和ACAT1基因的表达可能是肉牛饲料效率的指标。

Ruminal expression of the NQO1, RGS5, and ACAT1 genes may be indicators of feed efficiency in beef steers.

作者信息

Kern R J, Zarek C M, Lindholm-Perry A K, Kuehn L A, Snelling W M, Freetly H C, Cunningham H C, Meyer A M

机构信息

University of Wyoming, Laramie, WY, USA.

USDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA.

出版信息

Anim Genet. 2017 Feb;48(1):90-92. doi: 10.1111/age.12490. Epub 2016 Sep 9.

DOI:10.1111/age.12490

PMID:27611366

Abstract

Ruminal genes differentially expressed in crossbred beef steers from USMARC with variation in gain and feed intake were identified in a previous study. Several of the genes identified with expression patterns differing between animals with high gain-low feed intake and low gain-high feed intake were evaluated in a separate, unrelated population of Angus × Hereford beef steers from the University of Wyoming that was classified to differ in residual feed intake (RFI). Of the 17 genes tested, two were differentially expressed by RFI class in the Angus × Hereford animals. These genes included NAD(P)H dehydrogenase, quinone 1 (NQO1; P = 0.0009) and regulator of G-protein signaling 5 (RGS5; P = 0.01). A third gene, acetyl-CoA acetyltransferase 1 (ACAT1; P = 0.06), displayed a trend toward association with RFI. These data suggest that some of the genes identified in a previous rumen transcriptome discovery study may have utility for identifying or selecting for animals with superior feed efficiency phenotypes across cattle breeds and populations.

摘要

在之前的一项研究中，已鉴定出美国肉类动物研究中心（USMARC）杂交肉牛中瘤胃基因的差异表达情况，这些肉牛在生长速度和采食量方面存在差异。在怀俄明大学的一个单独的、不相关的安格斯×海福特肉牛群体中，对一些在高生长速度-低采食量和低生长速度-高采食量的动物之间表达模式不同的基因进行了评估，该群体根据剩余采食量（RFI）进行了分类。在测试的17个基因中，有两个基因在安格斯×海福特动物中因RFI类别而表现出差异表达。这些基因包括NAD(P)H脱氢酶醌1（NQO1；P = 0.0009）和G蛋白信号调节因子5（RGS5；P = 0.01）。第三个基因，乙酰辅酶A乙酰转移酶1（ACAT1；P = 0.06），显示出与RFI相关的趋势。这些数据表明，在之前的瘤胃转录组发现研究中鉴定出的一些基因，可能有助于在不同牛品种和群体中鉴定或选择具有优异饲料效率表型的动物。