Meikle A W, Smith J A, Stringham J D
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132.
J Steroid Biochem. 1989 Jul;33(1):19-24. doi: 10.1016/0022-4731(89)90352-x.
We recently observed a familial influence on the plasma concentration of sex-steroids and the metabolic clearance in men with prostatic cancer. We have now determined, by isotope dilution techniques, the blood estradiol and testosterone production and clearance rates in men with prostatic cancer and in unrelated controls. Thirty-eight men had a diagnosis of prostatic cancer before the age of 63, and 22 controls matched for age were randomly selected from the general population. None of the patients or controls had received endocrine therapy. The plasma content of testosterone, dihydrotestosterone, estrone, estradiol, 3 alpha-androstanediol glucuronide, dehydroepiandrosterone sulfate, sex-hormone binding globulin, apparent free testosterone concentration, follicle stimulating hormone and luteinizing hormone were not significantly different between the groups. The metabolic clearance and production rates of testosterone were significantly (P = 0.008 and P = 0.013, respectively) higher in patients [447 +/- 26 L/day/body surface area(m2) and 2.21 +/- 0.17 mg/day/m2, n = 38] than in controls [346 +/- 20 L/day/m2 and 1.70 +/- 0.11 mg/day/m2, n = 22]. The PR and MCR of estradiol were not significantly different between patients with prostatic cancer (n = 19) and controls (n = 12). These results indicate that men with prostatic cancer have elevated clearance and production rates of testosterone without an alteration of estradiol production or clearance.
我们最近观察到家族因素对前列腺癌男性患者的血浆性类固醇浓度及代谢清除率存在影响。我们现在通过同位素稀释技术测定了前列腺癌男性患者及无关对照者的血液雌二醇和睾酮生成及清除率。38名男性在63岁之前被诊断为前列腺癌，从普通人群中随机选取了22名年龄匹配的对照者。患者和对照者均未接受过内分泌治疗。两组之间睾酮、双氢睾酮、雌酮、雌二醇、3α-雄烷二醇葡萄糖醛酸苷、硫酸脱氢表雄酮、性激素结合球蛋白、表观游离睾酮浓度、促卵泡激素和黄体生成素的血浆含量无显著差异。患者组[447±26升/天/体表面积（m²）和2.21±0.17毫克/天/m²，n = 38]的睾酮代谢清除率和生成率显著高于对照组[346±20升/天/m²和1.70±0.11毫克/天/m²，n = 22]（P分别为0.008和0.013）。前列腺癌患者（n = 19）和对照组（n = 12）之间雌二醇的生成率和代谢清除率无显著差异。这些结果表明，前列腺癌男性患者的睾酮清除率和生成率升高，而雌二醇的生成或清除未发生改变。
