Meikle A W, Smith J A, West D W
Prostate. 1985;6(2):121-8. doi: 10.1002/pros.2990060202.
Whether familial factors affect the frequency of prostatic cancer and the plasma content of sex-steroids was investigated. Brothers (n = 257) of probands (n = 150) diagnosed with prostatic cancer before age 62 years had a fourfold higher risk for developing the disease than men in the general population in the State of Utah and their brothers-in-law (n = 202). Familial factors markedly affected the plasma content of sex steroids (testosterone, dihydrotestosterone, the ratio of testosterone to DHT, sex-hormone binding globulin, and the free fraction of testosterone) in nonendocrinologically treated probands and their brothers and sons and in normal men in the general populations. Index cases and their brothers and sons had a significantly lower mean plasma testosterone content than controls of comparable age. Preliminary data suggest that the metabolic clearance rate of testosterone and the conversion ratio of testosterone to estradiol are relatively high in probands. The observations indicate that familial factors are potent risk factors for the development of prostatic cancer. They also suggest that plasma androgen values in families with prostatic cancer cluster in the lower range of normal and that plasma sex-steroid content is more similar in each brothers with or without prostatic cancer than among nonbrothers.
研究了家族因素是否会影响前列腺癌的发病率以及性类固醇的血浆含量。在犹他州，先证者（n = 150）在62岁之前被诊断患有前列腺癌，其兄弟（n = 257）患该病的风险是普通人群及其姐夫（n = 202）的四倍。家族因素显著影响了未经内分泌治疗的先证者及其兄弟和儿子以及普通人群中正常男性的性类固醇血浆含量（睾酮、双氢睾酮、睾酮与双氢睾酮的比值、性激素结合球蛋白以及睾酮的游离部分）。索引病例及其兄弟和儿子的平均血浆睾酮含量显著低于同龄对照组。初步数据表明，先证者中睾酮的代谢清除率和睾酮向雌二醇的转化率相对较高。这些观察结果表明，家族因素是前列腺癌发生的有力危险因素。它们还表明，前列腺癌家族中的血浆雄激素值聚集在正常范围的较低水平，并且患有或未患有前列腺癌的兄弟之间的血浆性类固醇含量比非兄弟之间更为相似。
