Shangguan Yongming, Sun Lina, Wan Peng, Tan Lili, Wang Chengyue, Fan Xinmin, Qin Ling, Yang Ke
Department of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China; Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China.
Jinzhou Medical University, Jinzhou 121000, China.
Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:95-107. doi: 10.1016/j.msec.2016.06.073. Epub 2016 Jun 23.
To solve the problem of rapid degradation for magnesium-based implants, surface modification especially coating method is widely studied and showed the great potential for clinical application. However, as concerned to the further application and medical translation for biodegradable magnesium alloys, there are still lack of data and comparisons among different coatings on their degradation and biological properties. This work studied three commonly used coatings on Mg-Sr alloy, including micro-arc oxidation coating, electrodeposition coating and chemical conversion coating, and compared these coatings for requirements of favorable degradation and biological performances, how each of these coating systems has performed. Finally the mechanism for the discrepancy between these coatings is proposed. The results indicate that the micro-arc oxidation coating on Mg-Sr alloy exhibited the best corrosion resistance and cell response among these coatings, and is proved to be more suitable for the orthopedic application.
为解决镁基植入物快速降解的问题，表面改性尤其是涂层方法得到了广泛研究，并显示出巨大的临床应用潜力。然而，关于可生物降解镁合金的进一步应用和医学转化，不同涂层在降解和生物学性能方面仍缺乏数据和比较。本研究对Mg-Sr合金上三种常用涂层进行了研究，包括微弧氧化涂层、电沉积涂层和化学转化涂层，并比较了这些涂层在良好降解和生物学性能方面的要求，以及每种涂层系统的表现。最后提出了这些涂层之间差异的机制。结果表明，Mg-Sr合金上的微弧氧化涂层在这些涂层中表现出最佳的耐腐蚀性和细胞反应，被证明更适合骨科应用。
