钯颗粒负载蒙脱石钠电极用于血液样本中布洛芬的分析：采用高效液相色谱法进行验证
Ibuprofen analysis in blood samples by palladium particles-impregnated sodium montmorillonite electrodes: Validation using high performance liquid chromatography.
作者信息
Loudiki A, Boumya W, Hammani H, Nasrellah H, El Bouabi Y, Zeroual M, Farahi A, Lahrich S, Hnini K, Achak M, Bakasse M, El Mhammedi M A
机构信息
Univ Hassan 1, Laboratoire de Chimie et Modélisation Mathématique, 25000 Khouribga, Morocco; Laboratoire de Chimie Organique Bioorganique et Environnement, Faculté de Sciences, Université Chouaib Doukkali, Morocco.
Univ Hassan 1, Laboratoire de Chimie et Modélisation Mathématique, 25000 Khouribga, Morocco; Ecole Nationale des Sciences Appliquées, Laboratoire des Sciences de l'Ingénieur Pour l'Energie, Université Chouaib Doukkali, El Jadida, Morocco.
出版信息
Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:616-24. doi: 10.1016/j.msec.2016.07.024. Epub 2016 Jul 13.
The electrochemical detection of ibuprofen has been studied on Palladium-Montmorillonite (Mt) modified carbon paste electrode using differential pulse voltammetry. The optimization of the modifier preparation and the instrumental parameters was investigated. The results indicate that ibuprofen oxidation was favored in the presence of Pd-PdO particles. The quantitative determination of ibuprofen was statistically analyzed and validated using HPLC method. The detection and quantification limits, specificity and precision were found to be acceptable. Finally, the developed method was successfully applied for ibuprofen determination in human blood samples.
采用差分脉冲伏安法，在钯-蒙脱石修饰碳糊电极上对布洛芬进行了电化学检测。研究了修饰剂制备和仪器参数的优化。结果表明，在钯-氧化钯颗粒存在下，布洛芬的氧化更有利。使用高效液相色谱法对布洛芬的定量测定进行了统计分析和验证。发现检测限、定量限、特异性和精密度均可接受。最后，所建立的方法成功应用于人体血液样本中布洛芬的测定。
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