Yang Yanqiu, He Fupo, Ye Jiandong
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, China.
Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:1004-9. doi: 10.1016/j.msec.2016.08.008. Epub 2016 Aug 4.
In this study, phosphate-based glass (PG) was used as a sintering aid for freeze-cast porous biphasic calcium phosphate (BCP) ceramic, which was sintered under a lower temperature (1000°C). The phase composition, pore structure, compressive strength, and cytocompatibility of calcium phosphate composite ceramics (PG-BCP) were evaluated. The results indicated that PG additive reacted with calcium phosphate during the sintering process, forming β-Ca2P2O7; the ions of sodium and magnesium from PG partially substituted the calcium sites of β-calcium phosphate in BCP. The PG-BCP showed good cytocompatibility. The pore width of the porous PG-BCP ceramics was around 50μm, regardless of the amount of PG sintering aid. As the content of PG increased from 0wt.% to 15wt.%, the compressive strength of PG-BCP increased from 0.02 MP to 0.28MPa. When the PG additive was 17.5wt.%, the compressive strength of PG-BCP dramatically increased to 5.66MPa. Addition of 15wt.% PG was the critical point for the properties of PG-BCP. PG is considered as an effective sintering aid for freeze-cast porous bioceramics.
在本研究中，磷酸盐基玻璃（PG）被用作冷冻铸造多孔双相磷酸钙（BCP）陶瓷的烧结助剂，该陶瓷在较低温度（1000°C）下烧结。对磷酸钙复合陶瓷（PG-BCP）的相组成、孔隙结构、抗压强度和细胞相容性进行了评估。结果表明，PG添加剂在烧结过程中与磷酸钙反应，形成β-Ca2P2O7；PG中的钠和镁离子部分取代了BCP中β-磷酸钙的钙位点。PG-BCP表现出良好的细胞相容性。无论PG烧结助剂的用量如何，多孔PG-BCP陶瓷的孔径约为50μm。随着PG含量从0wt.%增加到15wt.%，PG-BCP的抗压强度从0.02MPa增加到0.28MPa。当PG添加剂为17.5wt.%时，PG-BCP的抗压强度急剧增加到5.66MPa。添加15wt.%的PG是PG-BCP性能的临界点。PG被认为是冷冻铸造多孔生物陶瓷的有效烧结助剂。
