School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China.
School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China.
Colloids Surf B Biointerfaces. 2018 Jul 1;167:318-327. doi: 10.1016/j.colsurfb.2018.04.028. Epub 2018 Apr 13.
β-tricalcium phosphate (β-TCP) is well known as a resorbable bone repair material due to its inherent excellent biocompatibility and osteoconductivity. However, β-TCP is encountered with osteostimulation-deficiency and poor mechanical strength because of poor sinterability. Herein, we prepared novel β-TCP composite ceramics (TCP/SPGs) by introducing strontium-containing phosphate-based glass (SPG; 45PO-32SrO-23NaO) as sintering additive. The SPG helped to achieve efficient liquid-phase sintering of β-TCP at 1100 °C. The compressive strength of TCP/SPGs with 15 wt.% SPG (TCP/SPG15) was 2.65 times as high as that of plain β-TCP ceramic. The SPG reacted with β-TCP, and the Sr and Na from SPG replaced Ca in the lattice structure of β-TCP, enabling the sustained release of strontium from TCP/SPGs. In vitro cytological test indicated that TCP/SPGs with certain amount of SPG were highly biocompatible, and noticeably promoted osteogenesis, and inhibited osteoclastic activities. Our results suggested that the TCP/SPG15 might be potential high-strength bone grafts used for bone defect repair, especially in the osteoporotic condition.
β-磷酸三钙（β-TCP）因其固有优异的生物相容性和骨诱导性而被广泛认为是一种可吸收的骨修复材料。然而，由于烧结性能差，β-TCP 存在成骨刺激不足和机械强度差的问题。在此，我们通过引入含锶磷酸盐基玻璃（SPG；45PO-32SrO-23NaO）作为烧结添加剂来制备新型β-TCP 复合陶瓷（TCP/SPGs）。SPG 有助于在 1100°C 下实现β-TCP 的高效液相烧结。添加 15wt.% SPG（TCP/SPG15）的 TCP/SPGs 的抗压强度比纯β-TCP 陶瓷高 2.65 倍。SPG 与β-TCP 反应，SPG 中的 Sr 和 Na 取代了β-TCP 晶格结构中的 Ca，从而使 Sr 能够从 TCP/SPGs 中持续释放。体外细胞学试验表明，具有一定 SPG 含量的 TCP/SPGs 具有良好的生物相容性，明显促进成骨作用，抑制破骨细胞活性。我们的结果表明，TCP/SPG15 可能是用于骨缺损修复的潜在高强度骨移植物，特别是在骨质疏松症的情况下。
