Abou Dalle Iman, Nassif Samer, Bazarbachi Ali
Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon.
Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Hematol Oncol Stem Cell Ther. 2018 Jun;11(2):99-104. doi: 10.1016/j.hemonc.2016.08.001. Epub 2016 Sep 2.
Pathologic increase in bone marrow reticulin fibrosis can be present in many malignant hematopoietic diseases. In acute leukemia, one-third of patients have some degree of marrow reticulin fibrosis at presentation, which is thought to be related to cytokine release from blasts. Marrow fibrosis is particularly common in acute megakaryoblastic leukemia, while this change is rarely seen in acute promyelocytic leukemia. Six case reports of acute promyelocytic leukemia with marrow reticulin fibrosis have been described so far in the literature. Herein, we present three cases of classical acute promyelocytic leukemia with increased marrow reticulin fibrosis encountered in our institution, summarizing their clinicopathologic features, treatment, and outcome to date. Awareness of the features of acute promyelocytic leukemia with marrow reticulin fibrosis is important as it may guide treatment options.
骨髓网硬蛋白纤维化的病理性增加可见于多种恶性造血疾病。在急性白血病中，三分之一的患者在初诊时存在一定程度的骨髓网硬蛋白纤维化，这被认为与原始细胞释放细胞因子有关。骨髓纤维化在急性巨核细胞白血病中尤为常见，而在急性早幼粒细胞白血病中这种变化很少见。迄今为止，文献中已描述了6例伴有骨髓网硬蛋白纤维化的急性早幼粒细胞白血病病例报告。在此，我们报告在本机构遇到的3例伴有骨髓网硬蛋白纤维化增加的经典急性早幼粒细胞白血病病例，总结其临床病理特征、治疗及目前的转归。认识伴有骨髓网硬蛋白纤维化的急性早幼粒细胞白血病的特征很重要，因为它可能指导治疗方案的选择。
