Zaĭchenko A M, Tugaĭ T I, Shliakhovoĭ V V
Mikrobiol Zh (1978). 1989 Mar-Apr;51(2):71-4.
Possibility of producing (14C)-macrocyclic trichothecenes (MCTC) with high specific activity was studied. (1-14C)-glucose, (2-14C)-acetate and (2-14C)-mevalonate were used as precursors. The best results were obtained when labeled acetate was introduced into the medium at the end of the logarithmic growth stage of Dendrodochium toxicum 5800, a fungus-producer. Individual (14C)-MCTC with high specific activity are obtained: verrucarine A-158.1 microC/mM, rhoridine A-167.4 microC/mM; rhoridine H-161.9 microC/mM.
研究了生产具有高比活度的（14C）-大环单端孢霉烯族毒素（MCTC）的可能性。使用（1-14C）-葡萄糖、（2-14C）-乙酸盐和（2-14C）-甲羟戊酸作为前体。当在真菌生产者Dendrodochium toxicum 5800的对数生长阶段末期将标记的乙酸盐引入培养基时，获得了最佳结果。得到了具有高比活度的单个（14C）-MCTC：疣孢菌素A-158.1微居里/毫摩尔，红镰菌素A-167.4微居里/毫摩尔；红镰菌素H-161.9微居里/毫摩尔。
