在同一地理区域的两个不同种族人群中，天疱疮的流行病学存在显著差异。

Remarkable differences in the epidemiology of pemphigus among two ethnic populations in the same geographic region.

机构信息

Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.

School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel.

出版信息

J Am Acad Dermatol. 2016 Nov;75(5):925-930. doi: 10.1016/j.jaad.2016.06.055. Epub 2016 Sep 7.

DOI:10.1016/j.jaad.2016.06.055

PMID:27614531

Abstract

BACKGROUND

The epidemiology of pemphigus in different ethnic populations exposed to similar environments is unknown. Trends in the incidence of pemphigus based on an immunopathologically validated cohort have not been investigated.

OBJECTIVES

We sought to estimate the incidence of pemphigus in Israel and to investigate differences between the 2 major ethnic populations.

METHODS

Pemphigus incidence was retrospectively estimated from January 2000 to December 2015 in 2 Israeli regions with a total population of 1.56 million inhabitants.

RESULTS

One hundred eighty patients with pemphigus (mean age, 54.70 ± 16 years) were identified. The overall estimated incidence was 7.2 per million inhabitants per year (95% confidence interval, 6.2-8.3). The incidence in the Jewish population was threefold higher than that in Arabs (9.6 vs 3.2 cases per million per year, respectively; P < .0001) and higher among women than men (9 vs 5.3 cases per million per year, respectively; P < .0001). The incidence decreased from 8.4 cases per million per year in 2000 to 2005 to 7.0 and 6.0 (95% confidence interval, 4.5-7.9) in 2006 to 2010 and 2011 to 2015, respectively (P = .068).

LIMITATIONS

This study was limited by the retrospective design and the small population.

CONCLUSIONS

The incidence of pemphigus in Israel is among the highest reported worldwide and is significantly more frequent among Jews.

摘要

背景

暴露于相似环境的不同种族人群中的天疱疮流行病学情况尚不清楚。基于免疫病理确诊队列的天疱疮发病率趋势尚未被研究过。

目的

我们旨在评估以色列的天疱疮发病率，并研究 2 大主要种族人群之间的差异。

方法

我们回顾性地估计了 2000 年 1 月至 2015 年 12 月期间以色列 2 个地区的天疱疮发病率，这 2 个地区的总人口为 156 万。

结果

共发现 180 例天疱疮患者（平均年龄 54.70 ± 16 岁）。总的估计发病率为每年每百万居民 7.2 例（95%置信区间，6.2-8.3）。犹太人群的发病率是阿拉伯人群的 3 倍（分别为每年每百万居民 9.6 和 3.2 例，P <.0001），女性发病率也高于男性（分别为每年每百万居民 9 和 5.3 例，P <.0001）。发病率从 2000 年至 2005 年的每年每百万 8.4 例降至 2006 年至 2010 年的每年每百万 7.0 例和 6.0 例（95%置信区间，4.5-7.9），再降至 2011 年至 2015 年的每年每百万 6.0 例（95%置信区间，4.5-7.9）（P =.068）。