Kridin Khalaf, Zelber-Sagi Shira, Bergman Reuven
Department of Dermatology, Rambam Health Care Campus, POB 9602, 31096 Haifa, Israel.
Acta Derm Venereol. 2017 Oct 2;97(9):1095-1099. doi: 10.2340/00015555-2706.
Little is known about differences in epidemiological features and prognosis between pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The objective of this study was to compare PV and PF patients regarding ethnic variations and mortality rates. Mortality of PV and PF patients was compared with age- and sex-matched control subjects in the general population. The study cohort comprised 207 patients with PV and 30 with PF diagnosed during the period 2000 to 2015. The incidence rate of PV among Jews was 3.6-fold higher than among Arabs (p<0.001), whereas no ethnic predisposition to PF was noted (p = 0.379). The risk of death for patients with PV was almost 3-fold higher than in the general population (standardized mortality ratio (SMR) 2.6). For patients with PF, the risk of mortality was not significantly increased relative to the general population (SMR 1.4). There is a racial predisposition to PV, whereas PF is sporadic. Mortality among patients with PV is higher compared with PF and the general population.
寻常型天疱疮（PV）和落叶型天疱疮（PF）在流行病学特征和预后方面的差异鲜为人知。本研究的目的是比较PV和PF患者在种族差异和死亡率方面的情况。将PV和PF患者的死亡率与普通人群中年龄和性别匹配的对照对象进行比较。研究队列包括2000年至2015年期间诊断出的207例PV患者和30例PF患者。犹太人中PV的发病率比阿拉伯人高3.6倍（p<0.001），而未发现PF有种族易感性（p = 0.379）。PV患者的死亡风险几乎比普通人群高3倍（标准化死亡率（SMR）为2.6）。对于PF患者，相对于普通人群，死亡风险没有显著增加（SMR为1.4）。PV存在种族易感性，而PF是散发性的。PV患者的死亡率高于PF患者和普通人群。
