Taddei Tamar H, Lo Re Vincent, Justice Amy C
Section of Digestive Diseases, VA Connecticut-Healthcare System, West Haven, CT, USA.
Section of Digestive Diseases, Yale University School of Medicine, 333 Cedar St., PO Box 208019, New Haven, CT, 06520-8019, USA.
Curr HIV/AIDS Rep. 2016 Oct;13(5):269-78. doi: 10.1007/s11904-016-0327-7.
Viral suppression of human immunodeficiency virus (HIV) with combination antiviral therapy (cART) has led to increasing longevity but has not enabled a complete return to health among aging HIV-infected individuals (HIV+). Viral coinfections are prevalent in the HIV+ host and are implicated in cancer, liver disease, and accelerated aging. We must move beyond a simplistic notion of HIV becoming a "chronic controllable illness" and develop an understanding of how viral suppression alters the natural history of HIV infection, especially at the intersection of HIV with other common viral coinfections in the context of an altered, aging immune system.
采用联合抗病毒疗法（cART）对人类免疫缺陷病毒（HIV）进行病毒抑制已延长了患者寿命，但在衰老的HIV感染者（HIV+）中，尚未实现完全恢复健康。病毒合并感染在HIV+宿主中很常见，与癌症、肝病和加速衰老有关。我们必须摒弃HIV已成为“慢性可控疾病”这种过于简单的观念，深入了解病毒抑制如何改变HIV感染的自然史，尤其是在免疫系统改变和衰老的背景下，HIV与其他常见病毒合并感染的情况。
