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腹腔镜肾盂成形术与开放肾盂成形术治疗儿童复发性输尿管肾盂连接处梗阻的比较

Laparoscopic pyeloplasty versus open pyeloplasty for recurrent ureteropelvic junction obstruction in children.

作者信息

Abdel-Karim A M, Fahmy A, Moussa A, Rashad H, Elbadry M, Badawy H, Hammady A

机构信息

Alexandria University, Egypt.

Alexandria University, Egypt.

出版信息

J Pediatr Urol. 2016 Dec;12(6):401.e1-401.e6. doi: 10.1016/j.jpurol.2016.06.010. Epub 2016 Jul 21.

Abstract

INTRODUCTION AND OBJECTIVES

Recurrent ureteropelvic junction obstruction (UPJO) in children is an operative challenge. Minimally invasive endourological treatment options for secondary UPJO have suboptimal success rates; hence, there is a re-emergence of interest about redo pyeloplasty. The present study presented experience with laparoscopic management of previously failed pyeloplasty compared with open redo pyeloplasty in children.

STUDY DESIGN

Twenty-four children with recurrent UPJO who underwent transperitoneal dismembered laparoscopic pyeloplasty were studied. Operative, postoperative, and follow-up functional details were recorded and compared with those of open pyeloplasty (n = 15) carried out for recurrent UPJO by the same surgeon during the same study period.

RESULTS

Demographic data were comparable in the laparoscopic and open groups, except for a significantly lower GFR in the open group (24.8 vs 38.2 ml/min, P = 0.0001). Mean time to failure of the original repair was 20.2 months (23.6 months for redo laparoscopic pyeloplasty, 18.8 months for redo open). The success rate of laparoscopic redo pyeloplasty was 91.7 vs 100% in open redo pyeloplasty. Compared with redo open pyeloplasty, the mean operative time was longer (211.4 ± 32.2 vs 148.8 ± 16.6, P = 0.002), estimated blood loss was higher (102 vs 75 ml, P = 0.06), while hospital stay was shorter and pain score was lower in the laparoscopy group (P = 0.02) in the laparoscopic group. There were no intraoperative complications, while the postoperative complication rate was similar in the two groups (20.8 vs 20.0%).

DISCUSSION

Before the laparoscopic approach became a viable option, endopyelotomy was widely used for managing recurrent UPJO. However, the success rate of endopyelotomy for secondary UPJO was approximately 10-25% lower than for open pyeloplasty. Redo pyeloplasty had excellent results, with reported success rates of 77.8-100%. Laparoscopic redo pyeloplasty is becoming a viable alternative to open redo pyeloplasty in many centers with experience in minimally invasive techniques. The present study revealed that redo laparoscopic pyeloplasty appeared to have advantages over redo open surgery, in that it was associated with shorter hospital stay (4 vs 6 days, P = 0.046), reduced postoperative pain score (P = 0.02), and less need for postoperative analgesia (P = 0.001), still with comparable successful outcomes and patient safety. However, the procedure had a longer operative times and more blood loss.

CONCLUSION

Laparoscopic pyeloplasty is a viable alternative to open pyeloplasty in children with recurrent UPJO, with shorter hospital stays and less postoperative pain. However, the procedure is technically demanding and should be attempted in high-volume centers by laparoscopists with considerable experience in laparoscopic reconstructive procedures.

摘要

引言与目的

儿童复发性肾盂输尿管连接部梗阻(UPJO)的手术治疗具有挑战性。对于继发性UPJO,微创腔内治疗方案的成功率并不理想;因此,再次肾盂成形术重新受到关注。本研究介绍了儿童腹腔镜治疗既往肾盂成形术失败病例的经验,并与开放再次肾盂成形术进行比较。

研究设计

对24例接受经腹离断式腹腔镜肾盂成形术的复发性UPJO患儿进行研究。记录手术、术后及随访的功能细节,并与同期由同一位外科医生为复发性UPJO实施的开放肾盂成形术(n = 15)的相关情况进行比较。

结果

腹腔镜组和开放手术组的人口统计学数据具有可比性,但开放手术组的肾小球滤过率(GFR)显著更低(分别为24.8与38.2 ml/min,P = 0.0001)。初次修复失败的平均时间为20.2个月(再次腹腔镜肾盂成形术为23.6个月,再次开放手术为18.8个月)。腹腔镜再次肾盂成形术的成功率为91.7%,而开放再次肾盂成形术为100%。与再次开放肾盂成形术相比,腹腔镜再次肾盂成形术的平均手术时间更长(分别为211.4 ± 32.2与148.8 ± 16.6分钟,P = 0.002),估计失血量更多(分别为102与75 ml,P = 0.06),而腹腔镜组的住院时间更短,疼痛评分更低(P = 0.02)。术中无并发症发生,两组术后并发症发生率相似(分别为20.8%与20.0%)。

讨论

在腹腔镜手术成为可行选择之前,肾盂内切开术广泛用于治疗复发性UPJO。然而,继发性UPJO的肾盂内切开术成功率比开放肾盂成形术约低10 - 25%。再次肾盂成形术效果良好,报道的成功率为77.8 - 100%。在许多具备微创技术经验的中心,腹腔镜再次肾盂成形术正成为开放再次肾盂成形术的可行替代方法。本研究表明,再次腹腔镜肾盂成形术似乎比再次开放手术具有优势,因为其住院时间更短(分别为4与6天,P = 0.046),术后疼痛评分降低(P = 0.02),术后镇痛需求更少(P = 0.001),且手术成功率和患者安全性相当。然而,该手术的手术时间更长,失血量更多。

结论

对于复发性UPJO患儿,腹腔镜肾盂成形术是开放肾盂成形术的可行替代方法,具有住院时间短和术后疼痛轻的优点。然而,该手术技术要求高,应由在腹腔镜重建手术方面经验丰富的腹腔镜医生在大型中心进行尝试。

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