Weinberg J, Adler A J
Department of Medicine, Brooklyn Veterans Administration Medical Center, State University of New York Health Science Center.
Miner Electrolyte Metab. 1989;15(4):185-6.
Following the introduction of the ASTRA automated chemical analyzer to the Brooklyn VA Hospital, we identified 14 patients with normal renal function and marked hyperphosphatemia (9.1 +/- 3.1 mg/dl). Reanalysis of these samples by standard SMA-II autoanalyzer demonstrated normal phosphate concentration (3.5 +/- 0.7 mg/dl). All patients had a dysglobulinemic syndrome and further examination indicated that ASTRA reagents produced significant optical turbidity in these sera. We conclude that chemical analysis of inorganic phosphorus by methods which do not deproteinate sera prior to colorimetric analysis are subject to nephelometry in the presence of dysglobulinemic samples and may result in spurious hyperphosphatemia.
在布鲁克林退伍军人医院引入ASTRA自动化学分析仪后，我们发现了14名肾功能正常但血磷显著升高（9.1±3.1mg/dl）的患者。用标准SMA-II自动分析仪对这些样本进行重新分析，结果显示血磷浓度正常（3.5±0.7mg/dl）。所有患者均患有球蛋白异常血症综合征，进一步检查表明，ASTRA试剂在这些血清中产生了明显的光学浊度。我们得出结论，在比色分析前未对血清进行脱蛋白处理的无机磷化学分析方法，在存在球蛋白异常血症样本的情况下会受到比浊法的影响，可能导致假性高磷血症。
