De Marinis L, Mancini A, Tofani A, Calabrò F, Sciuto R, Bellantone R, Sofo L, Goglia A, Rabitti C, Montemaggi P
Minerva Endocrinol. 1989 Apr-Jun;14(2):129-35.
The association of hyperthyroidism and thyroid carcinoma, especially multicentric forms, is an unusual event. We present the case of a 49-year-old woman with clinical and radiological findings of hyperfunctioning thyroid nodule that showed, after a subtotal thyroidectomy, histologic evidence of multicentric carcinoma in one lobe and adenoma in the other lobe. The interest of this clinical case is in the coexistence of an independent adenoma with a multicentric carcinoma, revealed by radical surgery that was necessary for the occurrence of a multinodular goiter. The incidence of this situation could be underestimated in consequence of the current surgical approach to the single "hot" nodule and suggests we pay attention to these patients for the possible presence of malignancy in functionally-inhibited thyroid tissue.
甲状腺功能亢进与甲状腺癌，尤其是多中心性甲状腺癌的关联是一种不常见的情况。我们报告一例49岁女性病例，其具有甲状腺功能亢进性结节的临床和影像学表现，在次全甲状腺切除术后，组织学证据显示一个叶为多中心癌，另一个叶为腺瘤。该临床病例的关注点在于独立腺瘤与多中心癌并存，这种情况通过根治性手术得以揭示，而根治性手术对于多结节性甲状腺肿的发生是必要的。由于目前针对单个“热”结节的手术方式，这种情况的发生率可能被低估，这提示我们要关注这些患者，因为在功能受抑制的甲状腺组织中可能存在恶性肿瘤。
