Stecker Mark M, Stevenson Matthew
Winthrop University Hospital, Department of Neuroscience, 222 Station Plaza North, Suite 407, Mineola, New York, 11530, USA.
Muscle Nerve. 2017 May;55(5):735-740. doi: 10.1002/mus.25401. Epub 2017 Jan 24.
Combined hyperglycemia and anoxia have a marked negative effect on peripheral nerve not seen with either alone. We studied whether nerve injury is related to the presence of hyperglycemia in the oxygenated state, anoxic state, or both.
We performed recordings of the nerve action potential (NAP) from rat sciatic nerve in a perfusion apparatus with different metabolic substrates during anoxia and oxygenated state.
The NAP was best preserved when one of the perfusates contained no glucose. Transient improvements were seen with normoglycemic perfusates or perfusates that contained substrates that were poorly used in glycolysis/gluconeogenesis. Hyperglycemia has important negative effects in both the oxygenated and anoxic states.
Deleterious effects of hyperglycemia on the peripheral nerve may relate to metabolic products produced during the oxygenated state, such as glycogen and the effects of reperfusion after prolonged periods of anoxic metabolism. Muscle Nerve, 2016 Muscle Nerve 55: 735-740, 2017.
高血糖与缺氧共同作用对周围神经有显著的负面影响，而单独的高血糖或缺氧则不会产生这种影响。我们研究了神经损伤是否与在氧合状态、缺氧状态或两者兼有的情况下高血糖的存在有关。
我们在灌注装置中，于缺氧和氧合状态下，使用不同代谢底物对大鼠坐骨神经进行神经动作电位（NAP）记录。
当一种灌注液不含葡萄糖时，NAP保存得最好。正常血糖灌注液或含有糖酵解/糖异生中利用不佳的底物的灌注液会出现短暂改善。高血糖在氧合和缺氧状态下均有重要的负面影响。
高血糖对周围神经的有害影响可能与氧合状态下产生的代谢产物有关，如糖原以及长时间缺氧代谢后再灌注的影响。《肌肉与神经》，2016年 2017年《肌肉与神经》55卷：735 - 740页
