Neuroscience Department, Winthrop University Hospital, 222 Station Plaza North, Suite 408, Mineola, New York, 11530, USA.
Muscle Nerve. 2014 Mar;49(3):370-7. doi: 10.1002/mus.23917. Epub 2013 Dec 16.
Glucose has a significant effect on nerve function.
The effects of glucose on the nerve action potential (NAP) were investigated for concentrations between 0 and 55.5 mmol/L in an in vitro system using rat sciatic nerve. The effects of glucose were investigated in nerves exposed to oxygenated perfusate and those subjected to anoxia. Multiple aspects of the NAP were analyzed.
Hypoglycemia produces immediate reductions in NAP amplitude and velocity, whereas hyperglycemia has the opposite effect in the short term. Over a 12-hour experiment, the amplitude of the NAP remained stable for glucose concentrations in the range 2.8-5.6 mmol/L, but, when the glucose concentration was <2.8 mmol/L or >27.8 mmol/L, the amplitude of the NAP declined. The deleterious effects of hyperglycemia (≥27.8 mmol/L) or hypoglycemia (<4.2 mmol/L) were more pronounced in nerves exposed to intermittent anoxia.
This findings confirm the importance of glucose concentration for nerve function especially during anoxia.
葡萄糖对神经功能有显著影响。
本研究采用大鼠坐骨神经在体外系统中，研究了浓度在 0 到 55.5mmol/L 之间的葡萄糖对神经动作电位（NAP）的影响。研究了在含氧灌注液中以及缺氧条件下暴露的神经中的葡萄糖作用。分析了 NAP 的多个方面。
低血糖会立即降低 NAP 的幅度和速度，而高血糖在短期内则有相反的影响。在 12 小时的实验中，当葡萄糖浓度在 2.8-5.6mmol/L 范围内时，NAP 的幅度保持稳定，但当葡萄糖浓度<2.8mmol/L 或>27.8mmol/L 时，NAP 的幅度下降。在间歇性缺氧的神经中，高血糖（≥27.8mmol/L）或低血糖（<4.2mmol/L）的有害影响更为明显。
这些发现证实了葡萄糖浓度对神经功能的重要性，特别是在缺氧期间。
