Volf Nina V, Belousova Ludmila V, Knyazev Gennady G, Kulikov Alexander V
State Scientific-Research Institute of Physiology and Basic Medicine, Timakova Street 4, Novosibirsk 630117, Russia; Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia.
State Scientific-Research Institute of Physiology and Basic Medicine, Timakova Street 4, Novosibirsk 630117, Russia.
Int J Psychophysiol. 2016 Nov;109:107-115. doi: 10.1016/j.ijpsycho.2016.09.002. Epub 2016 Sep 9.
This study was aimed to localize the effects of 5-HTTLPR (serotonin-transporter-linked polymorphic region) on the age differences of spontaneous EEG activity in women using neuroimaging analysis sLORETA (Standardized Low Resolution brain Electromagnetic Tomography). DNA samples extracted from cheek swabs and resting-state EEG recorded at 60 standard leads were collected from young (YW, N=86, 18-35years) and older (OW, N=45; 55-80years) healthy women. We have shown that advanced age was associated with increased posterior EEG desynchronization in S'/S'. S' (LG allele was grouped with S alleles owing to its functional equivalence and this group was labeled as S') genotype carriers denoted by decrease of delta - beta1 current source density, and to a lesser extent in L/L homozygotes denoted by decrease in delta activity. In heterozygotes OW, as compared with heterozygotes YW, higher source density estimates of beta1 in frontal and temporal cortex were observed. Age differences were more pronounced in the right hemisphere in S'/S' and L/L carriers and in the left hemisphere in heterozygotes. We also found that in OW, current source density estimates of theta, alpha1, alpha2, alpha3 and beta1 sources in the right occipital lobe were higher in S'/L than in S'/S' carriers. These results may have implications for understanding 5-HTT-dependent variation in the effect of aging on brain activity.
本研究旨在利用神经影像学分析标准化低分辨率脑电磁断层扫描（sLORETA），定位5-羟色胺转运体基因连锁多态性区域（5-HTTLPR）对女性自发脑电图活动年龄差异的影响。从年轻（YW，N = 86，18 - 35岁）和年长（OW，N = 45；55 - 80岁）健康女性的脸颊拭子中提取DNA样本，并记录60个标准导联的静息态脑电图。我们已经表明，高龄与S'/S'中后部脑电图去同步化增加有关。S'（由于其功能等效性，LG等位基因与S等位基因归为一组，该组标记为S'）基因型携带者表现为δ - β1电流源密度降低，而L/L纯合子中δ活动降低程度较小则表现得不太明显。与杂合子YW相比，杂合子OW在额叶和颞叶皮质中β1源密度估计值更高。S'/S'和L/L携带者在右半球以及杂合子在左半球年龄差异更为明显。我们还发现，在OW中，右枕叶中θ、α1、α2、α3和β1源电流源密度估计值在S'/L携带者中高于S'/S'携带者。这些结果可能有助于理解5-HTT对衰老对大脑活动影响的依赖性变化。
