Laboratory of Psychophysiology of Individual Differences, Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia; Laboratory of Behavioral Neurogenomics, Institute of Cytology and Genetics, Novosibirsk, Russia.
Laboratory of Psychophysiology of Individual Differences, Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia; Humanitarian Institute, Novosibirsk State University, Novosibirsk, Russia.
Brain Res. 2018 Oct 15;1697:67-75. doi: 10.1016/j.brainres.2018.06.018. Epub 2018 Jun 15.
The S allele of serotonin transporter gene (5-HTTLPR) has been found to increase the risk of depression and other mental health problems, but some evidence suggests that S-allele carriers outperform subjects carrying the long allele in an array of cognitive tasks. Evidence linking this polymorphism with individual variation in electrophysiological properties of resting state brain networks is very limited. This study investigated the effect of 5-HTTLPR polymorphism on EEG current source density, connectivity, and topological properties of resting state networks. We collected genetic and resting state EEG data in 113 Caucasians. As compared to L-homozygotes, S-allele carriers showed lower current source density and connectivity in most frequency bands in areas overlapping with the default mode and emotion regulation regions. The analysis of graph-theoretical measures showed that S-allele carriers, as compared to L-homozygotes, have less optimal topological properties of brain networks in theta, but more optimal in alpha band. This dissociation may reflect the predisposition to emotional disorders, which is inherent to S-allele carriers, and, on the other hand, their superior functioning in some cognitive domains.
5-羟色胺转运体基因（5-HTTLPR）的 S 等位基因已被发现会增加患抑郁症和其他心理健康问题的风险，但有证据表明，在一系列认知任务中，S 等位基因携带者的表现优于携带长等位基因的受试者。将这种多态性与静息态大脑网络的个体电生理特性的个体差异联系起来的证据非常有限。本研究调查了 5-HTTLPR 多态性对静息态脑电图电流源密度、连通性和网络拓扑特性的影响。我们在 113 名白种人中收集了遗传和静息状态脑电图数据。与 L 纯合子相比，S 等位基因携带者在与默认模式和情绪调节区域重叠的区域中，在大多数频率带的电流源密度和连通性较低。图论测量的分析表明，与 L 纯合子相比，S 等位基因携带者的大脑网络在 theta 波段的拓扑性质较差，但在 alpha 波段的拓扑性质较好。这种分离可能反映了 S 等位基因携带者固有的情绪障碍倾向，另一方面，他们在某些认知领域的表现更优。
