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内源性多巴胺的树突体释放:A10多巴胺区域的体内透析

Somatodendritic release of endogenous dopamine: in vivo dialysis in the A10 dopamine region.

作者信息

Kalivas P W, Bourdelais A, Abhold R, Abbott L

机构信息

Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520.

出版信息

Neurosci Lett. 1989 May 22;100(1-3):215-20. doi: 10.1016/0304-3940(89)90687-3.

Abstract

Using in vivo dialysis in the A10 region of the anesthetized rat, somatodendritic release of endogenous dopamine was demonstrated. Although endogenous dopamine release from the A10 region was enhanced by amphetamine pretreatment in a dose-related manner, the amount of dopamine released was markedly less than the axonal release of dopamine measured simultaneously in the nucleus accumbens.

摘要

在麻醉大鼠的A10区域使用体内透析法,证实了内源性多巴胺的树突体释放。尽管预先给予苯丙胺以剂量相关的方式增强了A10区域内源性多巴胺的释放,但释放的多巴胺量明显少于同时在伏隔核中测量的多巴胺轴突释放量。

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