混合物、代谢物与机制：利用斑马鱼理解毒理学
Mixtures, Metabolites, and Mechanisms: Understanding Toxicology Using Zebrafish.
作者信息
Gamse Joshua T, Gorelick Daniel A
机构信息
1 Department of Reproductive Toxicology, Drug Safety Evaluation, Bristol-Myers Squibb , New Brunswick, New Jersey.
2 Department of Pharmacology and Toxicology, University of Alabama at Birmingham , Birmingham, Alabama.
出版信息
Zebrafish. 2016 Oct;13(5):377-8. doi: 10.1089/zeb.2016.1370.
Abstract
For more than 60 years, zebrafish have been used in toxicological studies. Due to their transparency, genetic tractability, and compatibility with high-throughput screens, zebrafish embryos are uniquely suited to study the effects of pharmaceuticals and environmental insults on embryonic development, organ formation and function, and reproductive success. This special issue of Zebrafish highlights the ways zebrafish are used to investigate the toxic effects of endocrine disruptors, pesticides, and heavy metals.
摘要
60多年来，斑马鱼一直被用于毒理学研究。由于其透明度、遗传易操作性以及与高通量筛选的兼容性，斑马鱼胚胎特别适合用于研究药物和环境损伤对胚胎发育、器官形成与功能以及繁殖成功的影响。《斑马鱼》的这一特刊重点介绍了利用斑马鱼研究内分泌干扰物、农药和重金属毒性作用的方法。
相似文献
1
Mixtures, Metabolites, and Mechanisms: Understanding Toxicology Using Zebrafish.混合物、代谢物与机制：利用斑马鱼理解毒理学
Zebrafish. 2016 Oct;13(5):377-8. doi: 10.1089/zeb.2016.1370.
2
Zebrafish as a Vertebrate Model System to Evaluate Effects of Environmental Toxicants on Cardiac Development and Function.斑马鱼作为一种脊椎动物模型系统，用于评估环境毒物对心脏发育和功能的影响。
Int J Mol Sci. 2016 Dec 16;17(12):2123. doi: 10.3390/ijms17122123.
3
Zebrafish as a model system to study toxicology.斑马鱼作为毒理学研究的模型系统。
Environ Toxicol Chem. 2014 Jan;33(1):11-7. doi: 10.1002/etc.2406. Epub 2013 Dec 4.
4
Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP).与暴露于持久性有机污染物（POP）天然混合物的雄性斑马鱼的发育和生殖效应相关的肝脏和睾丸中的转录调控。
J Toxicol Environ Health A. 2009;72(3-4):112-30. doi: 10.1080/15287390802537255.
5
A multivariate assessment of innate immune-related gene expressions due to exposure to low concentration individual and mixtures of four kinds of heavy metals on zebrafish (Danio rerio) embryos.对斑马鱼（Danio rerio）胚胎暴露于低浓度四种重金属单一物质及其混合物后先天免疫相关基因表达的多变量评估。
Fish Shellfish Immunol. 2015 Dec;47(2):1032-42. doi: 10.1016/j.fsi.2015.11.003. Epub 2015 Nov 6.
6
Zebrafish (Danio rerio) neuromast: promising biological endpoint linking developmental and toxicological studies.斑马鱼（Danio rerio）的神经丘：连接发育毒理学研究的有前途的生物学终点。
Aquat Toxicol. 2009 Dec 13;95(4):307-19. doi: 10.1016/j.aquatox.2009.04.007. Epub 2009 Apr 24.
7
Zebrafish as the toxicant screening model: Transgenic and omics approaches.斑马鱼作为毒物筛选模型：转基因和组学方法。
Aquat Toxicol. 2021 May;234:105813. doi: 10.1016/j.aquatox.2021.105813. Epub 2021 Mar 20.
8
Fish as a model to assess chemical toxicity in bone.鱼类作为评估骨骼中化学物质毒性的模型。
Aquat Toxicol. 2018 Jan;194:208-226. doi: 10.1016/j.aquatox.2017.11.015. Epub 2017 Nov 26.
9
Analysis of the Enantioselective Effects of PCB95 in Zebrafish (Danio rerio) Embryos through Targeted Metabolomics by UPLC-MS/MS.通过超高效液相色谱-串联质谱联用的靶向代谢组学分析多氯联苯95对斑马鱼胚胎的对映体选择性影响
PLoS One. 2016 Aug 8;11(8):e0160584. doi: 10.1371/journal.pone.0160584. eCollection 2016.
10
Parental exposure to natural mixtures of persistent organic pollutants (POP) induced changes in transcription of apoptosis-related genes in offspring zebrafish embryos.亲代暴露于持久性有机污染物（POP）的天然混合物会导致斑马鱼后代胚胎中凋亡相关基因的转录发生变化。
J Toxicol Environ Health A. 2016;79(13-15):602-11. doi: 10.1080/15287394.2016.1171991.
引用本文的文献
1
Sustained effects of developmental exposure to inorganic arsenic on hepatic gsto2 expression and mating success in zebrafish.发育性暴露于无机砷对斑马鱼肝脏 gst02 表达和交配成功率的持续影响。
Biol Open. 2024 Mar 1;13(3). doi: 10.1242/bio.060094. Epub 2024 Mar 6.
2
Augmentation of Pectoral Fin Teratogenicity by Thalidomide in Human Cytochrome P450 3A-Expressing Zebrafish.沙利度胺对表达人细胞色素P450 3A的斑马鱼胸鳍致畸性的增强作用。
Pharmaceuticals (Basel). 2023 Feb 28;16(3):368. doi: 10.3390/ph16030368.
3
Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action.暴露于具有不同作用模式的复杂食物相关化学品混合物中的斑马鱼胚胎中颅面畸形的剂量添加。
Environ Health Perspect. 2022 Apr;130(4):47003. doi: 10.1289/EHP9888. Epub 2022 Apr 8.
4
Toxicological Parameters of a Formulation Containing Cinnamaldehyde for Use in Treatment of Oral Fungal Infections: An Study.含肉桂醛制剂治疗口腔真菌感染的毒理学参数：一项研究。
Biomed Res Int. 2021 Oct 22;2021:2305695. doi: 10.1155/2021/2305695. eCollection 2021.
5
Sub-lethal Camphor Exposure Triggers Oxidative Stress, Cardiotoxicity, and Cardiac Physiology Alterations in Zebrafish Embryos.低剂量樟脑暴露会引发斑马鱼胚胎的氧化应激、心脏毒性和心脏生理学改变。
Cardiovasc Toxicol. 2021 Nov;21(11):901-913. doi: 10.1007/s12012-021-09682-x. Epub 2021 Aug 2.
6
A decade of toxicological trends: what the papers say.十年毒理学趋势：论文如是说。
Toxicol Res (Camb). 2020 Oct 8;9(5):676-682. doi: 10.1093/toxres/tfaa063. eCollection 2020 Sep.
7
LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.小鱼，大数据：斑马鱼作为心血管和代谢疾病的模型
Physiol Rev. 2017 Jul 1;97(3):889-938. doi: 10.1152/physrev.00038.2016.
8
Zebrafish in Toxicology and Environmental Health.斑马鱼在毒理学与环境卫生领域的应用
Curr Top Dev Biol. 2017;124:331-367. doi: 10.1016/bs.ctdb.2016.10.007. Epub 2016 Dec 21.
本文引用的文献
1
Histological and Transcriptomic Changes in Male Zebrafish Testes Due to Early Life Exposure to Low Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.幼年暴露于低水平2,3,7,8-四氯二苯并对二恶英对雄性斑马鱼睾丸的组织学和转录组学变化
Zebrafish. 2016 Oct;13(5):413-23. doi: 10.1089/zeb.2016.1275.
2
DNA Damage Assessment in Zebrafish Embryos Exposed to Monceren(®) 250 SC Fungicide Using the Alkaline Comet Assay.使用碱性彗星试验评估暴露于Monceren(®) 250 SC杀菌剂的斑马鱼胚胎中的DNA损伤。
Zebrafish. 2016 Oct;13(5):442-8. doi: 10.1089/zeb.2016.1265. Epub 2016 Aug 24.
3
Evaluation of the Biotoxicity of Tree Wood Ashes in Zebrafish Embryos.树木灰烬对斑马鱼胚胎的生物毒性评估。
Zebrafish. 2016 Oct;13(5):449-55. doi: 10.1089/zeb.2016.1255. Epub 2016 Aug 3.
4
Screening of Toxic Effects of Bisphenol A and Products of Its Degradation: Zebrafish (Danio rerio) Embryo Test and Molecular Docking.双酚A及其降解产物的毒性效应筛选：斑马鱼（Danio rerio）胚胎试验与分子对接
Zebrafish. 2016 Oct;13(5):466-74. doi: 10.1089/zeb.2016.1261. Epub 2016 Aug 3.
5
High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance of Intact Zebrafish Embryos Detects Metabolic Changes Following Exposure to Teratogenic Polymethoxyalkenes from Algae.完整斑马鱼胚胎的高分辨率魔角旋转核磁共振检测暴露于藻类致畸聚甲氧基烯烃后的代谢变化。
Zebrafish. 2016 Oct;13(5):456-65. doi: 10.1089/zeb.2016.1280. Epub 2016 Jun 27.
6
Roundup(®) in Zebrafish: Effects on Oxidative Status and Gene Expression.草甘膦除草剂（农达）对斑马鱼的影响：对氧化状态和基因表达的作用
Zebrafish. 2016 Oct;13(5):432-41. doi: 10.1089/zeb.2016.1259. Epub 2016 Jun 17.
7
Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis.探寻胎儿酒精谱系障碍：斑马鱼作为乙醇致畸作用的模型
Zebrafish. 2016 Oct;13(5):391-8. doi: 10.1089/zeb.2016.1270. Epub 2016 May 17.
8
The Effect of Chronic Arsenic Exposure in Zebrafish.慢性砷暴露对斑马鱼的影响。
Zebrafish. 2016 Oct;13(5):405-12. doi: 10.1089/zeb.2016.1252. Epub 2016 May 3.
9
Cardiac Toxicity of Triclosan in Developing Zebrafish.三氯生对斑马鱼幼体的心脏毒性
Zebrafish. 2016 Oct;13(5):399-404. doi: 10.1089/zeb.2016.1257. Epub 2016 Apr 20.
10
Developmental Toxicity of Triclosan in the Presence of Dissolved Organic Carbon: Moving Beyond Standard Acute Toxicity Assays to Understand Ecotoxicological Risk.三氯生在溶解有机碳存在下的发育毒性：超越标准急性毒性试验以理解生态毒理学风险。
Zebrafish. 2016 Oct;13(5):424-31. doi: 10.1089/zeb.2015.1220. Epub 2016 Apr 5.
Zotero 插件