Gamse Joshua T, Gorelick Daniel A
1 Department of Reproductive Toxicology, Drug Safety Evaluation, Bristol-Myers Squibb , New Brunswick, New Jersey.
2 Department of Pharmacology and Toxicology, University of Alabama at Birmingham , Birmingham, Alabama.
Zebrafish. 2016 Oct;13(5):377-8. doi: 10.1089/zeb.2016.1370.
For more than 60 years, zebrafish have been used in toxicological studies. Due to their transparency, genetic tractability, and compatibility with high-throughput screens, zebrafish embryos are uniquely suited to study the effects of pharmaceuticals and environmental insults on embryonic development, organ formation and function, and reproductive success. This special issue of Zebrafish highlights the ways zebrafish are used to investigate the toxic effects of endocrine disruptors, pesticides, and heavy metals.
60多年来，斑马鱼一直被用于毒理学研究。由于其透明度、遗传易操作性以及与高通量筛选的兼容性，斑马鱼胚胎特别适合用于研究药物和环境损伤对胚胎发育、器官形成与功能以及繁殖成功的影响。《斑马鱼》的这一特刊重点介绍了利用斑马鱼研究内分泌干扰物、农药和重金属毒性作用的方法。
