Key Laboratory of Reservoir Aquatic Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China.
Environ Toxicol Chem. 2014 Jan;33(1):11-7. doi: 10.1002/etc.2406. Epub 2013 Dec 4.
Monitoring and assessing the effects of contaminants in the aquatic eco-environment is critical in protecting human health and the environment. The zebrafish has been widely used as a prominent model organism in different fields because of its small size, low cost, diverse adaptability, short breeding cycle, high fecundity, and transparent embryos. Recent studies have demonstrated that zebrafish sensitivity can aid in monitoring environmental contaminants, especially with the application of transgenic technology in this area. The present review provides a brief overview of recent studies on wild-type and transgenic zebrafish as a model system to monitor toxic heavy metals, endocrine disruptors, and organic pollutants for toxicology. The authors address the new direction of developing high-throughput detection of genetically modified transparent zebrafish to open a new window for monitoring environmental pollutants.
监测和评估水生态环境中的污染物对保护人类健康和环境至关重要。由于其体型小、成本低、适应性强、繁殖周期短、繁殖力强、胚胎透明等特点，斑马鱼已被广泛用作不同领域的重要模式生物。最近的研究表明，斑马鱼的敏感性有助于监测环境污染物，特别是在该领域应用转基因技术的情况下。本综述简要介绍了利用野生型和转基因斑马鱼作为监测毒理学中有毒重金属、内分泌干扰物和有机污染物的模型系统的最新研究。作者提出了开发高通量检测转基因透明斑马鱼的新方向，为监测环境污染物开辟了新的窗口。
